ArticleInternational journal of colorectal disease2017
Preoperative anaemia and perioperative red blood cell transfusion as prognostic factors for recurrence and mortality in colorectal cancer-a Swedish cohort study.
Article in International journal of colorectal disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Red blood cell transfusions and the survival in patients with cancer undergoing curative surgery: a systematic review and meta-analysis.Surgery today · 2021Pooled it
- Perioperative transfusion and the prognosis of colorectal cancer surgery: a systematic review and meta-analysis.World journal of surgical oncology · 2019Pooled it
- Impact of iron deficiency on therapeutic outcomes in colorectal cancer patients: a single-center cohort study.Journal of translational medicine · 2025Article
- Morphological Characteristics of Colon Tumors in Mice with Different Tolerance to Hypoxia.Bulletin of experimental biology and medicine · 2024Article
- Preoperative intravenous iron treatment - a cohort study on colorectal cancer recurrence.Surgery open science · 2023Article
- Is restrictive transfusion sufficient in colorectal cancer surgery? A retrospective study before and during the COVID-19 pandemic in Korea.Annals of coloproctology · 2023Article
- Lower need for allogeneic blood transfusion after robotic low anterior resection compared with open low anterior resection: a propensity score-matched analysis.Journal of robotic surgery · 2023Article
- Preoperative anemia and long-term survival in patients undergoing colorectal cancer surgery: a retrospective cohort study.World journal of surgical oncology · 2023Article
- Before-and-After Study of the First Four Years of the Enhanced Recovery after Surgery (ERASInternational journal of environmental research and public health · 2022Article
- Effect of a Patient Blood Management system on perioperative transfusion practice and short-term outcomes of colorectal cancer surgery.Blood transfusion = Trasfusione del sangue · 2022Article
- Effect of peri-operative blood transfusions on long-term prognosis of patients with colorectal cancer.Blood transfusion = Trasfusione del sangue · 2022Article
- Anemia tolerance versus blood transfusion on long-term outcomes after colorectal cancer surgery: A retrospective propensity-score-matched analysis.Frontiers in oncology · 2022Article
- Anemia can predict the prognosis of colorectal cancer in the pre-operative stage: a retrospective analysis.World journal of surgical oncology · 2021Article
- Do Preoperative Transfusions Impact Prognosis in Moderate to Severe Anaemic Surgical Patients with Colon Cancer?Current oncology (Toronto, Ont.) · 2021Article
- Impact of postoperative complications after primary tumor resection on survival in patients with incurable stage IV colorectal cancer: A multicenter retrospective cohort study.Annals of gastroenterological surgery · 2021Article
- Article
- Perioperative Blood Transfusion is Associated with Postoperative Systemic Inflammatory Response and Poorer Outcomes Following Surgery for Colorectal Cancer.Annals of surgical oncology · 2020Observational
- Association of preoperative anemia and perioperative allogenic red blood cell transfusion with oncologic outcomes in patients with nonmetastatic colorectal cancer.Current oncology (Toronto, Ont.) · 2019Observational
- Patient Blood Management improves outcome in oncologic surgery.World journal of surgical oncology · 2018Article
- Preoperative anemia in colorectal cancer: relationships with tumor characteristics, systemic inflammation, and survival.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe hypothesis in this study was that anaemia prior to surgery and perioperative red blood cell transfusion increases the risk for recurrence and overall mortality in patients with stages I-III colorectal cancer after abdominal resection with curative intent.
methodsThis is a Swedish single centre retrospective cohort study. Data on 496 consecutive radical abdominal resections stages I-III colorectal cancer performed at the Karolinska University Hospital 2007-2010 were extracted from the Swedish Colorectal Cancer Registry. Data were linked to local laboratory and transfusion databases to identify preoperative anaemia and perioperative transfusion. Disease recurrence was validated by scrutiny of patient records. A total of 496 stages I-III colorectal cancer patients were included in the analysis. Multivariate Cox regression analysis adjusted for tumour and patient characteristics were performed to assess risk for recurrence and overall mortality.
resultsAnaemia prior to surgery was associated with increased risk for overall mortality (HR 2.1, 95% CI 1.4-3.2). There was no association between anaemia and risk for recurrence (HR 1.6, 95% CI 0.97-2.6). Transfusion was not associated with increased risk of recurrence (HR 0.7, 95% CI 0.4-1.3) or overall mortality (HR 1.04, 95% CI 0.7-1.6).
conclusionsAnaemia prior to colorectal cancer surgery was associated with increased risk for overall mortality while a no increased risk was seen for recurrence. Previous findings indicating an association between blood transfusion and increased risk for recurrence could not be confirmed.
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