Evidence map›Paper›PMID 27770235›Full record

ArticleActa neuropathologica2017

Deep sequencing reveals persistence of cell-associated mumps vaccine virus in chronic encephalitis.

Sofia Morfopoulou, Edward T Mee, Sarah M Connaughton, Julianne R Brown, Kimberly Gilmour, W K 'Kling' Chong, W Paul Duprex, Deborah Ferguson, Mike Hubank, Ciaran Hutchinson and 11 more

Open access · hybridAbstract readCase Reports
In one paragraph

Article in Acta neuropathologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  15. Monogenic susceptibility to live viral vaccines.Current opinion in immunology · 2021
    Review
  16. Benchmark of thirteen bioinformatic pipelines for metagenomic virus diagnostics using datasets from clinical samples.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 7 institutions in 2 countries.

Sofia MorfopoulouDivision of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK. sofia.morfopoulou.10@ucl.ac.uk.ORCID 0000-0001-8181-4548
Edward T MeeVirology Division, National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK.
Sarah M ConnaughtonVirology Division, National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK.
Julianne R BrownMicrobiology, Virology and Infection Control, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
Kimberly GilmourDepartment of Immunology, Great Ormond Street Hospital, NHS Foundation Trust, London, WC1N 3JH, UK.
W K 'Kling' ChongDepartment of Radiology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
W Paul DuprexDepartment of Microbiology, Boston University School of Medicine, Boston, MA, 02118, USA.
Deborah FergusonVirology Division, National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK.
Mike HubankGenetics and Genomics Medicine UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
Ciaran HutchinsonDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
Marios KaliakatsosNeurosciences Department, Great Ormond Street Hospital, NHS Foundation Trust, London, WC1N 3JH, UK.
Stephen McQuaidMolecular Pathology Programme, Centre for Cancer Research and Cell Biology, Queen's University, Belfast, UK.
Simon PaineDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
Vincent PlagnolUCL Genetics Institute, University College London, London, WC1E 6BT, UK.
Christopher RuisDivision of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
Alex VirasamiDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
Hong ZhanMolecular and Cellular Immunology Section, UCL Great Ormond Street Institute of Child Health, London, WC1N 1EH, UK.
Thomas S JacquesDepartment of Histopathology, Great Ormond Street Hospital for Children, NHS Foundation Trust, London, WC1N 3JH, UK.
Silke SchepelmannVirology Division, National Institute for Biological Standards and Control, Potters Bar, EN6 3QG, UK.
Waseem QasimGreat Ormond Street Hospital for Children, NHS Foundation Trust, Molecular and Cellular Immunology, London, WC1N 3JH, UK.
Judith BreuerDivision of Infection and Immunity, University College London, Cruciform Building, Gower Street, London, WC1E 6BT, UK.
Great Ormond Street Hospital for Children NHS Foundation Trust · GBGreat Ormond Street Hospital · GBNational Institute for Biological Standards and Control · GBUniversity College London · GBBoston University · USNottingham University Hospitals NHS Trust · GBQueen's University Belfast · GB

Funding

Shifting a Paradigm in Vaccine Safety: From Empirical to Rational AttenuationR01AI099100 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DUPREX, WILLIAM PAUL · 2013 to 2017
$2.0M
Department of Health RP-2014-05-007NIAID NIH HHS R01 AI099100
6 · The paper itself

Abstract

Routine childhood vaccination against measles, mumps and rubella has virtually abolished virus-related morbidity and mortality. Notwithstanding this, we describe here devastating neurological complications associated with the detection of live-attenuated mumps virus Jeryl Lynn (MuV

Indexed as

BiopsyBrainChronic DiseaseEncephalitis, ViralFatal OutcomeHigh-Throughput Nucleotide SequencingHumansInfantMaleMumps VaccineMumps virusSevere Combined ImmunodeficiencyMumps Vaccine

Identifiers

PMID27770235
PMCPMC5209397
OpenAlexW2533445864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.