Evidence map›Paper›PMID 27770164›Full record

ArticleAbdominal radiology (New York)2017

Diffusion-weighted endorectal MR imaging at 3T for prostate cancer: correlation with tumor cell density and percentage Gleason pattern on whole mount pathology.

Daniel I Glazer, Elmira Hassanzadeh, Andriy Fedorov, Olutayo I Olubiyi, Shayna S Goldberger, Tobias Penzkofer, Trevor A Flood, Paul Masry, Robert V Mulkern, Michelle S Hirsch and 2 more

Abstract read
In one paragraph

Article in Abdominal radiology (New York), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Quantitative Imaging Informatics for Cancer Research.JCO clinical cancer informatics · 2020
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Daniel I GlazerDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA. diglazer@partners.org.
Elmira HassanzadehDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Andriy FedorovDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Olutayo I OlubiyiDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Shayna S GoldbergerDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Tobias PenzkoferDepartment of Radiology, Charité University Hospital, Berlin, Germany.
Trevor A FloodDivision of Anatomical Pathology, The Ottawa Hospital, Ottawa, ON, K1H 8L6, Canada.
Paul MasryDepartment of Pathology, Humber River Hospital, Toronto, ON, M3M 0B2, Canada.
Robert V MulkernDepartment of Radiology, Boston Children's Hospital, Boston, MA, 02115, USA.
Michelle S HirschDepartment of Pathology, Brigham and Women's Hospital , Boston, MA, USA.
Clare M TempanyDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Fiona M FennessyDepartment of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Brigham and Women's Hospital · USBoston Children's Hospital · USCharité - Universitätsmedizin Berlin · DEDana-Farber Cancer Institute · USHumber River Regional Hospital · CAUniversity of Ottawa · CA

Funding

Image Guided Therapy Center - Ultrasound-based sensor system for the monitoring of COVID-19 patientsP41EB015898 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI TEMPANY, CLARE M · 2012 to 2021
$18.9M
IMAGE GUIDED THERAPY CENTERP41RR019703 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI JOLESZ, FERENC A · 2010 to 2011
$8.6M
Multidisciplinary Training in Image-Guided TherapyR25CA089017 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2001 to 2017
$7.8M
Quantitative Image Informatics for Cancer Research (QIICR)U24CA180918 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FEDOROV, ANDRIY, KIKINIS, RON · 2013 to 2017
$4.0M
Quantitiative MRI of prostate cancer as a biomarker and guide for treatmentU01CA151261 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI FENNESSY, FIONA · 2010 to 2014
$1.8M
NCI NIH HHS R25 CA089017NCI NIH HHS U01 CA151261NCI NIH HHS U24 CA180918NCRR NIH HHS P41 RR019703NIBIB NIH HHS P41 EB015898
6 · The paper itself

Abstract

objectiveTo determine if tumor cell density and percentage of Gleason pattern within an outlined volumetric tumor region of interest (TROI) on whole-mount pathology (WMP) correlate with apparent diffusion coefficient (ADC) values on corresponding TROIs outlined on pre-operative MRI.

methodsMen with biopsy-proven prostate adenocarcinoma undergoing multiparametric MRI (mpMRI) prior to prostatectomy were consented to this prospective study. WMP and mpMRI images were viewed using 3D Slicer and each TROI from WMP was contoured on the high b-value ADC maps (b0, 1400). For each TROI outlined on WMP, TCD (tumor cell density) and the percentage of Gleason pattern 3, 4, and 5 were recorded. The ADC

resultsNineteen patients with 21 tumors were included in this study. ADC

conclusionDWI MRI can characterize focal prostate cancer using ADC

Indexed as

AdenocarcinomaAgedContrast MediaDiffusion Magnetic Resonance ImagingGadolinium DTPAHumansMaleMiddle AgedNeoplasm GradingProspective StudiesProstatectomyProstatic NeoplasmsContrast MediaGadolinium DTPAADCDWIGleason patternMRIProstate cancer

Identifiers

PMID27770164
PMCPMC5357151
OpenAlexW2535092071

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.