ArticleG3 (Bethesda, Md.)2016
Microenvironmental Gene Expression Plasticity Among Individual Drosophila melanogaster.
Article in G3 (Bethesda, Md.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Family-based selection: an efficient method for increasing phenotypic variability.G3 (Bethesda, Md.) · 2025Article
- Gene expression variation across genetically identical individuals predicts reproductive traits.eLife · 2025Article
- An Integrated Database for Exploring Alternative Promoters in Animals.Scientific data · 2025Article
- Genetic, Environmental, and Stochastic Components of Lifespan Variability: TheInternational journal of molecular sciences · 2024Review
- Viruses in LaboratoryViruses · 2023Article
- Nonlinear expression patterns and multiple shifts in gene network interactions underlie robust phenotypic change in Drosophila melanogaster selected for night sleep duration.PLoS computational biology · 2023Article
- Stochastic Modeling of Gene Expression Evolution Uncovers Tissue- and Sex-Specific Properties of Expression Evolution in theJournal of computational biology : a journal of computational molecular cell biology · 2023Article
- Environment-driven shifts in interindividual variation and phenotypic integration within subnetworks of the mussel transcriptome and proteome.Molecular ecology · 2022Article
- Transcriptome diversity is a systematic source of variation in RNA-sequencing data.PLoS computational biology · 2022Article
- Shedding Light on Inter-Individual Variability of Olfactory Circuits inFrontiers in behavioral neuroscience · 2022Review
- Article
- Phenotypic and Transcriptomic Responses to Stress Differ According to Population Geography in an Invasive Species.Genome biology and evolution · 2021Article
- Identification of Genes Contributing to a Long Circadian Period inJournal of biological rhythms · 2021Article
- Differential gene expression in Drosophila melanogaster and D. nigrosparsa infected with the same Wolbachia strain.Scientific reports · 2021Article
- Article
- Behavior Individuality: A Focus onFrontiers in physiology · 2021Review
- Using single-plant-omics in the field to link maize genes to functions and phenotypes.Molecular systems biology · 2020Article
- Transcriptomics of Tasmanian Devil (Genes · 2019Article
- Widespread inter-individual gene expression variability inMolecular systems biology · 2019Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Differences in phenotype among genetically identical individuals exposed to the same environmental condition are often noted in genetic studies. Despite this commonplace observation, little is known about the causes of this variability, which has been termed microenvironmental plasticity. One possibility is that stochastic or technical sources of variance produce these differences. A second possibility is that this variation has a genetic component. We have explored gene expression robustness in the transcriptomes of 730 individual Drosophila melanogaster of 16 fixed genotypes, nine of which are infected with Wolbachia Three replicates of flies were grown, controlling for food, day/night cycles, humidity, temperature, sex, mating status, social exposure, and circadian timing of RNA extraction. Despite the use of inbred genotypes, and carefully controlled experimental conditions, thousands of genes were differentially expressed, revealing a unique and dynamic transcriptional signature for each individual fly. We found that 23% of the transcriptome was differentially expressed among individuals, and that the variability in gene expression among individuals is influenced by genotype. This transcriptional variation originated from specific gene pathways, suggesting a plastic response to the microenvironment; but there was also evidence of gene expression differences due to stochastic fluctuations. These observations reveal previously unappreciated genetic sources of variability in gene expression among individuals, which has implications for complex trait genetics and precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.