Evidence map›Paper›PMID 27769999›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2017

Cardiomyopathy-related mutation (A30V) in mouse cardiac troponin T divergently alters the magnitude of stretch activation in α- and β-myosin heavy chain fibers.

Alexis V Mickelson, Sampath K Gollapudi, Murali Chandra

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 4 citations in OpenAlex.

  1. Guidelines for authors and reviewers on antibody use in physiology studies.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexis V MickelsonDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Sampath K GollapudiDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington.
Murali ChandraDepartment of Integrative Physiology and Neuroscience, Washington State University, Pullman, Washington murali@vetmed.wsu.edu.
Washington State University · US

Funding

Mechanistic Understanding of Troponin T Role in Cardiac Thin Filament ActivationR01HL075643 · NHLBI · WASHINGTON STATE UNIVERSITY · PI CHANDRA, MURALI · 2004 to 2012
$2.7M
NHLBI NIH HHS R01 HL075643
6 · The paper itself

Abstract

The present study investigated the functional consequences of the human hypertrophic cardiomyopathy (HCM) mutation A28V in cardiac troponin T (TnT). The A28V mutation is located within the NH NEW & NOTEWORTHY: The differential impact of α- and β-myosin heavy chain (MHC) on contractile dynamics causes a mutant cardiac troponin T (TnT

Indexed as

AnimalsBlotting, WesternCalciumCardiomyopathy, HypertrophicMaleMiceMice, TransgenicMutationMyocardial ContractionMyocytes, CardiacMyosin Heavy ChainsProtein IsoformsTropomyosinTroponinTroponin TCalciumMyh6 protein, mouseMyh7 protein, mouseMyosin Heavy ChainsProtein IsoformsTropomyosinTroponinTroponin Ttroponin-tropomyosin complexcross-bridge recruitmentdilated cardiomyopathyhypertrophic cardiomyopathymyosin heavy chaintroponin T

Identifiers

PMID27769999
PMCPMC5283911
OpenAlexW2537324826

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.