ArticleAmerican journal of physiology. Heart and circulatory physiology2017
Exaggerated coronary vasoconstriction limits muscle metaboreflex-induced increases in ventricular performance in hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 22 citations in OpenAlex.
- Exercise, Prostaglandin ECells · 2026Review
- Effect of Acute Grape Seed Extract Supplementation on Heart Rate Recovery in Young Individuals.Journal of cardiovascular development and disease · 2025Article
- Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction.American journal of physiology. Heart and circulatory physiology · 2024Article
- Altered Autonomic Function in Metabolic Syndrome: Interactive Effects of Multiple Components.Journal of clinical medicine · 2024Review
- Muscle metaboreflex stimulates the cardiac sympathetic afferent reflex causing positive feedback amplification of sympathetic activity: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2024Article
- Augmented sympathoexcitation slows postexercise heart rate recovery.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Blood flow restriction training activates the muscle metaboreflex during low-intensity sustained exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Chronic ablation of TRPV1-sensitive skeletal muscle afferents attenuates the muscle metaboreflex.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Ventricular contraction and relaxation rates during muscle metaboreflex activation in heart failure: are they coupled?Experimental physiology · 2021Article
- Recent advances in exercise pressor reflex function in health and disease.Autonomic neuroscience : basic & clinical · 2020Review
- Enhanced dimethylarginine degradation improves coronary flow reserve and exercise tolerance in Duchenne muscular dystrophy carrier mice.American journal of physiology. Heart and circulatory physiology · 2020Article
- Muscle metaboreflex-induced increases in effective arterial elastance: effect of heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Guidelines for animal exercise and training protocols for cardiovascular studies.American journal of physiology. Heart and circulatory physiology · 2020Review
- Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise.American journal of physiology. Heart and circulatory physiology · 2020Review
- Statistical considerations in reporting cardiovascular research.American journal of physiology. Heart and circulatory physiology · 2018Article
- Neural Control of Cardiovascular Function During Exercise in Hypertension.Frontiers in physiology · 2018Review
- The Impact of Cardiovascular Diseases on Cardiovascular Regulation During Exercise in Humans: Studies on Metaboreflex Activation Elicited by the Post-exercise Muscle Ischemia Method.Current cardiology reviews · 2017Review
- Blood flow restriction training and the exercise pressor reflex: a call for concern.American journal of physiology. Heart and circulatory physiology · 2015Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Increases in myocardial oxygen consumption during exercise mainly occur via increases in coronary blood flow (CBF) as cardiac oxygen extraction is high even at rest. However, sympathetic coronary constrictor tone can limit increases in CBF. Increased sympathetic nerve activity (SNA) during exercise likely occurs via the action of and interaction among activation of skeletal muscle afferents, central command, and resetting of the arterial baroreflex. As SNA is heightened even at rest in subjects with hypertension (HTN), we tested whether HTN causes exaggerated coronary vasoconstriction in canines during mild treadmill exercise with muscle metaboreflex activation (MMA; elicited by reducing hindlimb blood flow by ~60%) thereby limiting increases in CBF and ventricular performance. Experiments were repeated after α NEW & NOTEWORTHY: We found that metaboreflex-induced increases in coronary blood flow and ventricular contractility are attenuated in hypertension. α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.