ArticleAmerican journal of epidemiology2016
Statistical Methods for Unusual Count Data: Examples From Studies of Microchimerism.
Article in American journal of epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Maternal microchimerism at birth associates with reduced odds of non-malarial fever and respiratory tract infections in Tanzanian children.PLOS global public health · 2026Article
- Exposure to Human Immunodeficiency Virus Is Associated With Altered Composition of Maternal Microchimeric T Cells in Infants.The Journal of infectious diseases · 2025Article
- Comparison of different statistical models for the analysis of fracture events: findings from the Prevention of Falls Injury Trial (PreFIT).BMC medical research methodology · 2023Article
- Markers of placental function correlate with prevalence and quantity of nucleated fetal cells in maternal circulation in normotensive term pregnancies.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Umbilical Cord Maternal Microchimerism in Normal and Preeclampsia Pregnancies.Reproductive sciences (Thousand Oaks, Calif.) · 2023Article
- Increased fetal microchimerism in immune and stem cell subsets in preeclampsia.American journal of reproductive immunology (New York, N.Y. : 1989) · 2023Article
- Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity.The Journal of clinical investigation · 2022Article
- Peripheral Plasmodium falciparum Infection in Early Pregnancy Is Associated With Increased Maternal Microchimerism in the Offspring.The Journal of infectious diseases · 2021Article
- countfitteR: efficient selection of count distributions to assess DNA damage.Annals of translational medicine · 2021Article
- Predictors of maternal-origin microchimerism in young women in the Philippines.American journal of physical anthropology · 2021Article
- Fetal microchimerism by mode of delivery: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2019Article
- Maternal Microchimerism Predicts Increased Infection but Decreased Disease due to Plasmodium falciparum During Early Childhood.The Journal of infectious diseases · 2017Article
- Maternal microchimerism is prevalent in cord blood in memory T cells and other cell subsets, and persists post-transplant.OncoimmunologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Natural acquisition of small amounts of foreign cells or DNA, referred to as microchimerism, occurs primarily through maternal-fetal exchange during pregnancy. Microchimerism can persist long-term and has been associated with both beneficial and adverse human health outcomes. Quantitative microchimerism data present challenges for statistical analysis, including a skewed distribution, excess zero values, and occasional large values. Methods for comparing microchimerism levels across groups while controlling for covariates are not well established. We compared statistical models for quantitative microchimerism values, applied to simulated data sets and 2 observed data sets, to make recommendations for analytic practice. Modeling the level of quantitative microchimerism as a rate via Poisson or negative binomial model with the rate of detection defined as a count of microchimerism genome equivalents per total cell equivalents tested utilizes all available data and facilitates a comparison of rates between groups. We found that both the marginalized zero-inflated Poisson model and the negative binomial model can provide unbiased and consistent estimates of the overall association of exposure or study group with microchimerism detection rates. The negative binomial model remains the more accessible of these 2 approaches; thus, we conclude that the negative binomial model may be most appropriate for analyzing quantitative microchimerism data.
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