Evidence map›Paper›PMID 27769649›Full record

ReviewParkinsonism & related disorders2016

Knowledge gaps and research recommendations for essential tremor.

Franziska Hopfner, Dietrich Haubenberger, Wendy R Galpern, Katrina Gwinn, Ashlee Van't Veer, Samantha White, Kailash Bhatia, Charles H Adler, David Eidelberg, William Ondo and 17 more

2 registry-linked trialsAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Parkinsonism & related disorders, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04692844 completednot on this mapstarted 2017, after this paper: background citation

The Mechanism of Tremor Modulating Properties of Propranolol and Primidone in Essential Tremor: A Study With Transcranial Magnetic Stimulation and Eye Blink Classical Conditioning Paradigm

TypeobservationalSponsorUniversity Medical Centre LjubljanaRan2017 to 2022Enrolled61ConditionsEssential TremorArmsPropranolol, Primidone
NCT06821906 phase2recruitingnot on this mapstarted 2024, after this paper: background citation

Stereotactic Radiosurgery in the Treatment of Tremor in Patients with Essential Tremor - a Randomized Phase II Study

TypeinterventionalSponsorMaria Sklodowska-Curie National Research Institute of OncologyRan2024 to 2030Enrolled42ConditionsEssential TremorArmsStereotactic Radiosurgery
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 58 citations in OpenAlex.

  1. Trial
  2. Prospective Home-use Study on Non-invasive Neuromodulation Therapy for Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2020
    Trial
  3. Article
  4. Article
  5. Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Cerebellar α6GABANeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Article
  10. Article
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Selective loss of the GABAJournal of neurophysiology · 2020
    Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 20 institutions in 4 countries.

Franziska HopfnerDepartment of Neurology, University Hospital Schleswig Holstein, Kiel, Germany.
Dietrich HaubenbergerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: dietrich.haubenberger@nih.gov.
Wendy R GalpernNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Katrina GwinnNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Ashlee Van't VeerNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Samantha WhiteNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Kailash BhatiaSobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College of London, United Kingdom.
Charles H AdlerMayo Clinic College of Medicine, Mayo Clinic Arizona, Scottsdale, AZ, USA.
David EidelbergThe Feinstein Institute for Medical Research, Manhasset, NY, USA.
William OndoMethodist Neurological Institute, Houston, TX, USA.
Glenn T StebbinsDepartment of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.
Caroline M TannerParkinson's Disease Research Education & Clinical Center, San Francisco Veterans Affairs Medical Center & Department of Neurology, University of California San Francisco, CA, USA.
Rick C HelmichRadboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Neurology, Nijmegen, The Netherlands.
Fred A LenzDepartment of Neurosurgery, Hopkins Hospital, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Roy V SillitoeDepartment of Pathology & Immunology, Department of Neuroscience, Program in Developmental Biology, Baylor College of Medicine, Houston, TX, USA.
David VaillancourtDepartment of Applied Physiology and Kinesiology, Center for Movement Disorders and Neurorestoration, Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA.
Jerrold L VitekDepartment of Neurology, University of Minnesota Medical School, Minneapolis, MN, USA.
Elan D LouisDepartment of Neurology, Department of Chronic Disease Epidemiology, Center for Neuroepidemiology and Clinical Neurological Research, Yale School of Medicine, Yale University, New Haven, CT, USA.
Holly A ShillDepartment of Neurology, Barrow Neurological Institute, Phoenix, AZ, USA.
Matthew P FroschC.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Boston, MA, USA.
Tatiana ForoudDepartment of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Gregor KuhlenbäumerDepartment of Neurology, University Hospital Schleswig Holstein, Kiel, Germany.
Andrew SingletonLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
Claudia M TestaParkinson's and Movement Disorders Center and Department of Neurology, Virginia Commonwealth University, Richmond, VA, USA.
Mark HallettNational Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Rodger ElbleDepartment of Neurology, Southern Illinois University School of Medicine, Springfield, IL, USA.
Günther DeuschlDepartment of Neurology, University Hospital Schleswig Holstein, Kiel, Germany.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · USUniversity Hospital Schleswig-Holstein · DEBarrow Neurological Institute · USBaylor College of Medicine · USFeinstein Institute for Medical Research · USHouston Methodist · USIndiana University School of MedicineJohns Hopkins Medicine · USMassachusetts General Hospital · USMayo Clinic in Arizona · USRadboud University Medical Center · NLRush University Medical Center · USSobell House · GBSouthern Illinois University School of Medicine · USUniversity of California, San Francisco · USUniversity of Florida · USUniversity of Lübeck · DEUniversity of Minnesota Medical Center · USVirginia Commonwealth University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
Indiana Clinical and Translational Sciences InstituteUL1TR001108 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI DENNE, SCOTT C., SHEKHAR, ANANTHA · 2013 to 2017
$23.3M
Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI NELSON, DAVID LOREN, NEUL, JEFFREY L · 2014 to 2019
$7.8M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
Intramural NIH HHS Z99 NS999999NCATS NIH HHS UL1 TR001108NCATS NIH HHS UL1 TR001863NICHD NIH HHS U54 HD083092NINDS NIH HHS R01 NS089664
6 · The paper itself

Abstract

Essential tremor (ET) is a common cause of significant disability, but its etiologies and pathogenesis are poorly understood. Research has been hampered by the variable definition of ET and by non-standardized research approaches. The National Institute of Neurological Disorders and Stroke (USA) invited experts in ET and related fields to discuss current knowledge, controversies, and gaps in our understanding of ET and to develop recommendations for future research. Discussion focused on phenomenology and phenotypes, therapies and clinical trials, pathophysiology, pathology, and genetics. Across all areas, the need for collaborative and coordinated research on a multinational level was expressed. Standardized data collection using common data elements for genetic, clinical, neurophysiological, and pathological studies was recommended. Large cohorts of patients should be studied prospectively to collect bio-samples, characterize the natural history of the clinical syndrome including patient-oriented outcomes, investigate potential etiologies of various phenotypes, and identify pathophysiological mechanisms. In particular, cellular and system-level mechanisms of tremor oscillations should be elucidated because they may yield effective therapeutic targets and biomarkers. A neuropathology consortium was recommended to standardize postmortem analysis and further characterize neuropathological observations in the cerebellum and elsewhere. Furthermore, genome-wide association studies on large patient cohorts (>10,000 patients) may allow the identification of common genes contributing to risk, and whole exome or genome sequencing may enable the identification of genetic risk and causal mutations in cohorts and well-characterized families.

Indexed as

Biomedical ResearchEssential TremorKnowledgeAnimalsHumansCommon data elementsEssential tremorGenetic association studiesNeuropathology

Identifiers

PMID27769649
PMCPMC5271603
OpenAlexW2529718642

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.