Evidence map›Paper›PMID 27769642›Full record

Observational studyJournal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia2017

COMT Val

Ethan A Winkler, John K Yue, Adam R Ferguson, Nancy R Temkin, Murray B Stein, Jason Barber, Esther L Yuh, Sourabh Sharma, Gabriela G Satris, Thomas W McAllister and 13 more

Open access · greenAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 5 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Review
  7. Article
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  17. Coronavirus syndrome: COVID-19 psychotrauma.European journal of translational myology · 2020
    Article
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Ethan A WinklerDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
John K YueDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Adam R FergusonDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Nancy R TemkinDepartment of Neurological Surgery and Biostatistics, University of Washington, Seattle, WA, USA.
Murray B SteinDepartment of Psychiatry, University of California, San Diego, San Diego, CA, USA; Department of Family and Preventative Medicine, University of California, San Diego, San Diego, CA, USA.
Jason BarberDepartment of Neurological Surgery and Biostatistics, University of Washington, Seattle, WA, USA.
Esther L YuhBrain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, San Francisco, CA, USA.
Sourabh SharmaDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Gabriela G SatrisDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Thomas W McAllisterDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA.
Jonathan RosandDepartment of Neurology, Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Marco D SoraniDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Hester F LingsmaDepartment of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands.
Phiroz E TaraporeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA.
Esteban G BurchardDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Donglei HuDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Celeste EngDepartment of Bioengineering and Therapeutic Sciences, University of California, San Francisco, San Francisco, CA, USA.
Kevin K W WangCenter for Neuroproteomics and Biomarkers Research, Departments of Psychiatry and Neuroscience, University of Florida, Gainesville, FL, USA.
Pratik MukherjeeBrain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, San Francisco, CA, USA.
David O OkonkwoDepartment of Neurological Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Ramon Diaz-ArrastiaDepartment of Neurology, Uniformed Services University of the Health Sciences, and Center for Neuroscience and Regenerative Medicine, Bethesda, MD, USA.
Geoffrey T ManleyDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA; Brain and Spinal Injury Center, San Francisco General Hospital, San Francisco, CA, USA. Electronic address: manleyg@neurosurg.ucsf.edu.
TRACK-TBI Investigators
San Francisco General Hospital · USUniversity of California, San Francisco · USUniversity of Washington · USBroad Institute · USErasmus MC · NLIndiana University School of MedicineUniformed Services University of the Health Sciences · USUniversity of Florida · USUniversity of Pittsburgh Medical Center · USUniversity of San Diego · US

Funding

Transforming Research and Clinical Knowledge in Traumatic Brain InjuryU01NS086090 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DIAZ-ARRASTIA, RAMON, GIACINO, JOSEPH THOMAS · 2013 to 2017
$19.1M
Transforming Traumatic Brain Injury Research and Clinical CareRC2NS069409 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MANLEY, GEOFFREY T · 2009 to 2011
$4.3M
NINDS NIH HHS RC2 NS069409NINDS NIH HHS U01 NS086090
6 · The paper itself

Abstract

Mild traumatic brain injury (mTBI) results in variable clinical trajectories and outcomes. The source of variability remains unclear, but may involve genetic variations, such as single nucleotide polymorphisms (SNPs). A SNP in catechol-o-methyltransferase (COMT) is suggested to influence development of post-traumatic stress disorder (PTSD), but its role in TBI remains unclear. Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether the COMT Val

Indexed as

Polymorphism, GeneticAdultAgedAllelesBrain Injuries, TraumaticCatechol O-MethyltransferaseEthnicityFemaleGlasgow Coma ScaleGlasgow Outcome ScaleHumansMaleMethionineMiddle AgedPolymorphism, Single NucleotideProspective StudiesCatechol O-MethyltransferaseCOMT protein, humanMethionineValineGenetic factorsHuman studiesOutcome measuresPTSDTraumatic brain injury

Identifiers

PMID27769642
PMCPMC5588892
OpenAlexW2537707735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.