Evidence map›Paper›PMID 27769520›Full record

ArticleJournal of pharmaceutical sciences2017

Combined Local Pulmonary and Systemic Delivery of AT2R Gene by Modified TAT Peptide Nanoparticles Attenuates Both Murine and Human Lung Carcinoma Xenografts in Mice.

Susumu Ishiguro, Nabil A Alhakamy, Deepthi Uppalapati, Jennifer Delzeit, Cory J Berkland, Masaaki Tamura

Open access · greenAbstract read
In one paragraph

Article in Journal of pharmaceutical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Peptide-Assisted Nucleic Acid Delivery Systems on the Rise.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Susumu IshiguroDepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Nabil A AlhakamyDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047.
Deepthi UppalapatiDepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Jennifer DelzeitDepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506.
Cory J BerklandDepartment of Pharmaceutical Chemistry, University of Kansas, Lawrence, Kansas 66047; Department of Chemical and Petroleum Engineering, University of Kansas, Lawrence, Kansas 66047.
Masaaki TamuraDepartment of Anatomy and Physiology, College of Veterinary Medicine, Kansas State University, Manhattan, Kansas 66506. Electronic address: mtamura@vet.ksu.edu.
Kansas State University · USUniversity of Kansas · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI Douglas E Wright · 2012 to 2026
$63.0M
Targeted nanoparticle gene therapy for lung cancerU43CA165462 · NCI · SAVARA, INC. · PI JOUHIKAINEN, TANELI, TAMURA, MASAAKI · 2013 to 2013
$190k
NCI NIH HHS U43 CA165462NIGMS NIH HHS P20 GM103418
6 · The paper itself

Abstract

To evaluate the potential of cell-penetrating peptide-based delivery of apoptosis-inducer gene in cancer therapy, a modified HIV-1 TAT peptide (dimerized TAT peptide, dTAT) was studied. The dTAT and plasmid DNA (pDNA) complexes (dTAT-pDNA) were condensed using calcium chloride (dTAT-pDNA-Ca

Indexed as

Gene Transfer TechniquesAnimalsCarcinoma, Lewis LungCell Line, TumorDNAGene ExpressionGenetic TherapyHIV-1HumansLungLung NeoplasmsMaleMiceMice, Inbred C57BLMice, SCIDNanoparticlesDNAReceptor, Angiotensin, Type 2tat Gene Products, Human Immunodeficiency Virusangiotensin II type 2 receptorapoptosisdTAT peptidelung cancernanoparticlesnonviral gene delivery

Identifiers

PMID27769520
PMCPMC5161536
OpenAlexW2537900975

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.