Evidence map›Paper›PMID 27769286›Full record

SynthesisReproductive biology and endocrinology : RB&E2016

Relationship between Advanced Glycation End Products and Steroidogenesis in PCOS.

Deepika Garg, Zaher Merhi

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Reproductive biology and endocrinology : RB&E, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  14. Protective effects of vanillic acid on letrozole-induced polycystic ovarian syndrome: A comprehensive study in female wistar rats.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Deepika GargDepartment of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, NY, 11219, USA.
Zaher MerhiDivision of Reproductive Biology, Department of Obstetrics and Gynecology, NYU School of Medicine, 180 Varick Street, sixth floor, New York City, NY, 11014, USA. zom00@hotmail.com.
Maimonides Medical Center · USNew York University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWomen with PCOS have elevated levels of the harmful Advanced Glycation End Products (AGEs), which are highly reactive molecules formed after glycation of lipids and proteins. Additionally, AGEs accumulate in the ovaries of women with PCOS potentially contributing to the well-documented abnormal steroidogenesis and folliculogenesis. MAIN BODY: A systematic review of articles and abstracts available in PubMed was conducted and presented in a systemic manner. This article reports changes in steroidogenic enzyme activity in granulosa and theca cells in PCOS and PCOS-models. It also described the changes in AGEs and their receptors in the ovaries of women with PCOS and presents the underlying mechanism(s) whereby AGEs could be responsible for the PCOS-related changes in granulosa and theca cell function thus adversely impacting steroidogenesis and follicular development. AGEs are associated with hyperandrogenism in PCOS possibly by altering the activity of various enzymes such as cholesterol side-chain cleavage enzyme cytochrome P450, steroidogenic acute regulatory protein, 17α-hydroxylase, and 3β-hydroxysteroid dehydrogenase. AGEs also affect luteinizing hormone receptor and anti-Mullerian hormone receptor expression as well as their signaling pathways in granulosa cells.

conclusionsA better understanding of how AGEs alter granulosa and theca cell function is likely to contribute meaningfully to a conceptual framework whereby new interventions to prevent and/or treat ovarian dysfunction in PCOS can ultimately be developed.

Indexed as

3-Hydroxysteroid DehydrogenasesAnimalsCholesterol Side-Chain Cleavage EnzymeFemaleGlycation End Products, AdvancedGonadal Steroid HormonesGranulosa CellsHumansOvaryPhosphoproteinsPolycystic Ovary SyndromeReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseSteroidogenic Acute Regulatory Protein3-Hydroxysteroid Dehydrogenasesanti-Mullerian hormone receptorCholesterol Side-Chain Cleavage EnzymeGlycation End Products, AdvancedGonadal Steroid HormonesPhosphoproteinsReceptors, LHReceptors, PeptideReceptors, Transforming Growth Factor betaSteroid 17-alpha-HydroxylaseSteroidogenic Acute Regulatory Protein17α-hydroxylase3β-hydroxysteroid dehydrogenaseAdvanced glycation end products (AGEs)AromataseCholesterol side-chain cleavage enzymePCOSRAGESteroidogenesisSteroidogenic acute regulatory protein (StAR)

Identifiers

PMID27769286
PMCPMC5073880
OpenAlexW2536288537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.