ArticleBMC systems biology2016
The potential for non-adaptive origins of evolutionary innovations in central carbon metabolism.
Article in BMC systems biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Wine Fermentation as a Model System for Microbial Ecology and Evolution.Environmental microbiology · 2025Review
- Environmental complexity is more important than mutation in driving the evolution of latent novel traits in E. coli.Nature communications · 2022Article
- Multiple Novel Traits without Immediate Benefits Originate in Bacteria Evolving on Single Antibiotics.Molecular biology and evolution · 2022Article
- Syntrophy emerges spontaneously in complex metabolic systems.PLoS computational biology · 2019Article
- Evolutionary design principles in metabolism.Proceedings. Biological sciences · 2019Review
- An enormous potential for niche construction through bacterial cross-feeding in a homogeneous environment.PLoS computational biology · 2018Article
- Factors driving metabolic diversity in the budding yeast subphylum.BMC biology · 2018Article
- Non-adaptive origins of evolutionary innovations increase network complexity in interacting digital organisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Constraint and Contingency Pervade the Emergence of Novel Phenotypes in Complex Metabolic Systems.Biophysical journal · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBiological systems are rife with examples of pre-adaptations or exaptations. They range from the molecular scale - lens crystallins, which originated from metabolic enzymes - to the macroscopic scale, such as feathers used in flying, which originally served thermal insulation or waterproofing. An important class of exaptations are novel and useful traits with non-adaptive origins. Whether such origins could be frequent cannot be answered with individual examples, because it is a question about a biological system's potential for exaptation. We here take a step towards answering this question by analyzing central carbon metabolism, and novel traits that allow an organism to survive on novel sources of carbon and energy. We have previously applied flux balance analysis to this system and predicted the viability of 10
resultsWe here use this exhaustive genotype-phenotype map to ask whether a central carbon metabolism that is viable on a given, focal carbon source C - the equivalent of an adaptation in our framework - is usually or rarely viable on one or more other carbon sources C
conclusionsA high potential for exaptation results from correlations between the phenotypes of different genotypes, and such correlations are frequent in central carbon metabolism. If they are similarly abundant in other metabolic or biological systems, innovations may frequently have non-adaptive ("exaptive") origins.
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