ArticleBMC microbiology2016
Characteristic of Enterococcus faecium clinical isolates with quinupristin/dalfopristin resistance in China.
Article in BMC microbiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 23 citations in OpenAlex.
- Comparison of Two Quinupristin-dalfopristin Susceptibility Testing Methods and Two Interpretive Criteria forAnnals of laboratory medicine · 2025Article
- Multidrug-resistant Enterococcus faecium strains enter the Norwegian marine environment through treated sewage.MicrobiologyOpen · 2024Article
- Phylogeny, Virulence, and Antimicrobial Resistance Gene Profiles ofAntibiotics (Basel, Switzerland) · 2023Article
- Prevalence and antimicrobial resistance patterns ofJAC-antimicrobial resistance · 2022Article
- Barriers to genetic manipulation of Enterococci: Current Approaches and Future Directions.FEMS microbiology reviews · 2022Review
- Antimicrobial Resistance ofJournal of veterinary research · 2022Article
- Antimicrobial Resistance in Porcine Enterococci in Australia and the Ramifications for Human Health.Applied and environmental microbiology · 2021Article
- Spread of Linezolid-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- A Conjugative MDR pMG1-Like Plasmid Carrying theFrontiers in microbiology · 2021Article
- Synthesis and biological evaluation of solithromycin analogs against multidrug resistant pathogens.Bioorganic & medicinal chemistry letters · 2019Article
- Antimicrobial Resistance and Virulence Genes inBioMed research international · 2019Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundQuinupristin/dalfopristin (Q/D) is a valuable alternative antibiotic to vancomycin for the treatment of multi-drug resistant Enterococcus faecium infections. However, resistance to Q/D in E. faecium clinical isolates and nosocomial dissemination of Q/D-resistant E. faecium have been reported in several countries and should be of concern.
resultsFrom January 2012 to December 2015, 911 E. faecium clinical isolates were isolated from various specimens of inpatients at the first Affiliated Hospital of Wenzhou Medical University located in Wenzhou, east China. Of 911 E. faecium clinical isolates, 9 (1.0 %, 9/911) were resistant to Q/D, with the Q/D MIC values of 64 mg/L(1), 32 mg/L(1), 16 mg/L(3), 8 mg/L(1) and 4 mg/L(3) determined by broth microdilution. All Q/D-resistant isolates were susceptible to vancomycin, tigecycline and teicoplanin but resistant to penicillin, ampicillin and erythromycin. vatE was only found in one Q/D-resistant E. faecium isolate while vatD was not detected in any of the isolates tested. 8 of 9 Q/D-resistant E. faecium isolates were found be positive for both ermB and msrC. The combinations of Q/D resistance determinants were ermB-msrC (7 isolates) and ermB-msrC-vatE (one isolate). ST78, ST761, ST94, ST21 and ST323 accounted for 4, 2, 1, 1 and 1 isolate, respectively, among which ST78 was the prevalent ST.
conclusionQ/D-resistant E. faecium clinical isolates were first described in China. Carriage of vatE, ermB and msrC was responsible for Q/D resistance.
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