Evidence map›Paper›PMID 27768841›Full record

ArticleChemical research in toxicology2016

O

Wenyan Xu, Daniel Kool, Derek K O'Flaherty, Ashley M Keating, Lauralicia Sacre, Martin Egli, Anne Noronha, Christopher J Wilds, Linlin Zhao

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyan Xu
Daniel Kool
Derek K O'FlahertyDepartment of Chemistry and Biochemistry, Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.
Ashley M Keating
Lauralicia SacreDepartment of Chemistry and Biochemistry, Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.
Martin EgliDepartment of Biochemistry, Vanderbilt University School of Medicine , Nashville, Tennessee 37232-0146, United States.
Anne NoronhaDepartment of Chemistry and Biochemistry, Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.
Christopher J WildsDepartment of Chemistry and Biochemistry, Concordia University , 7141 Sherbrooke Street West, Montréal, Québec H4B 1R6, Canada.
Linlin Zhao

Funding

Synthetic Approaches to Carcinogen-Linked OligonucleotidesP01CA160032 · NCI · VANDERBILT UNIVERSITY · PI STONE, MICHAEL P · 2012 to 2022
$14.0M
NCI NIH HHS P01 CA160032
6 · The paper itself

Abstract

DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and for developing effective chemotherapies. Previous research has focused on ICLs cross-linked with the N7 and N2 atoms of guanine as well as those formed at the N6 atom of adenine; however, little is known about the mutagenicity of O

Indexed as

DNA DamageDNA ReplicationAlkenesCells, CulturedChromatography, LiquidDeoxyguanosineDNA-Directed DNA PolymeraseDNA RepairHumansMass SpectrometryMutagensMutationY-Family DNA PolymerasesAlkenesbutyleneDeoxyguanosineDNA-Directed DNA PolymeraseMutagensRad30 proteinY-Family DNA Polymerases

Identifiers

PMID27768841
PMCPMC5665164

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.