Evidence map›Paper›PMID 27768825›Full record

ReviewAnnals of the New York Academy of Sciences2017

Genomic and functional techniques to mine the microbiome for novel antimicrobials and antimicrobial resistance genes.

Boahemaa Adu-Oppong, Andrew J Gasparrini, Gautam Dantas

Abstract readReview
In one paragraph

Review in Annals of the New York Academy of Sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Microbial metabolites: cause or consequence in gastrointestinal disease?American journal of physiology. Gastrointestinal and liver physiology · 2022
    Review
  5. The Gut Microbiome as a Reservoir for Antimicrobial Resistance.The Journal of infectious diseases · 2021
    Review
  6. Review
  7. Antibiotic Resistance in Recreational Waters: State of the Science.International journal of environmental research and public health · 2020
    Review
  8. Combining structure and genomics to understand antimicrobial resistance.Computational and structural biotechnology journal · 2020
    Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Complete Genome Sequence ofGenome announcements · 2018
    Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Boahemaa Adu-OppongCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri.
Andrew J GasparriniCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri.
Gautam DantasCenter for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri.

Funding

TRAINING PROGRAM IN CELLULAR AND MOLECULAR BIOLOGYT32GM007067 · NIGMS · WASHINGTON UNIVERSITY · PI TRUE-KROB, HEATHER L · 1985 to 2020
$20.4M
STRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESU01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2020 to 2025
$4.1M
STRUCTURAL, MECHANISTIC, & EVOLUTIONARY CHARACTERIZATION OF TETRACYCLINE DESTRUCTASESR01AI123394 · NIAID · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM, WENCEWICZ, TIMOTHY ADAM · 2016 to 2019
$2.7M
METAGENOMIC ENGINEERING OF PROBIOTIC BACTERIA TO IMPROVE INTESTINAL COLONIZATIONDP2DK098089 · NIDDK · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM · 2012 to 2012
$2.1M
ESTABLISHMENT AND DYNAMICS OF ANTIBIOTIC RESISTANCE RESERVOIRS IN DEVELOPING INTER01GM099538 · NIGMS · WASHINGTON UNIVERSITY · PI DANTAS, GAUTAM · 2013 to 2016
$1.2M
NIAID NIH HHS R01 AI123394NIAID NIH HHS U01 AI123394NIDDK NIH HHS DP2 DK098089NIGMS NIH HHS R01 GM099538NIGMS NIH HHS T32 GM007067
6 · The paper itself

Abstract

Microbial communities contain diverse bacteria that play important roles in every environment. Advances in sequencing and computational methodologies over the past decades have illuminated the phylogenetic and functional diversity of microbial communities from diverse habitats. Among the activities encoded in microbiomes are the abilities to synthesize and resist small molecules, yielding antimicrobial activity. These functions are of particular interest when viewed in light of the public health emergency posed by the increase in clinical antimicrobial resistance and the dwindling antimicrobial discovery and approval pipeline, and given the intimate ecological and evolutionary relationship between antimicrobial biosynthesis and resistance. Here, we review genomic and functional methods that have been developed for accessing the antimicrobial biosynthesis and resistance capacity of microbiomes and highlight outstanding examples of their applications.

Indexed as

Anti-Infective AgentsDrug ResistanceGenomicsMicrobiotaAnti-Infective Agentsantimicrobial resistanceantimicrobialsmetagenomicsmicrobiome

Identifiers

PMID27768825
PMCPMC5280215

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.