Evidence map›Paper›PMID 27768791›Full record

ArticleInvestigative ophthalmology & visual science2016

Extraocular Muscle Compartments in Superior Oblique Palsy.

Soh Youn Suh, Robert A Clark, Alan Le, Joseph L Demer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Investigative ophthalmology & visual science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

  1. Functional Anatomy of Ocular Counter-Rolling in Superior Oblique Palsy.Investigative ophthalmology & visual science · 2025
    Article
  2. Masquerading Superior Oblique Palsy.American journal of ophthalmology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Soh Youn SuhDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
Robert A ClarkDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 2David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
Alan LeDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 3Neuroscience Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 4Bioengineering Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
Joseph L DemerDepartment of Ophthalmology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 2David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 3Neuroscience Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 4Bioengineering Interdepartmental Program, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 5Stein Eye Institute, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California 6Department of Neurology, David Geffen Medical School at University of California, Los Angeles, Los Angeles, California.
University of California, Los Angeles · US

Funding

BIOMECHANICAL ANALYSIS IN STRABISMUS SURGERYR01EY008313 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI JOSEPH Louis DEMER · 1991 to 2026
$15.0M
NEI NIH HHS R01 EY008313
6 · The paper itself

Abstract

purposeTo investigate changes in volumes of extraocular muscle (EOM) compartments in unilateral superior oblique (SO) palsy using magnetic resonance imaging (MRI).

methodsHigh-resolution, surface-coil MRI was obtained in 19 patients with unilateral SO palsy and 19 age-matched orthotropic control subjects. Rectus EOMs and the SO were divided into two anatomic compartments for volume analysis in patients with unilateral SO palsy, allowing comparison of total compartmental volumes versus controls. Medial and lateral compartmental volumes of the SO muscle were compared in patients with isotropic (round shape) versus anisotropic (elongated shape) SO atrophy.

resultsThe medial and lateral compartments of the ipsilesional SO muscles were equally atrophic in isotropic SO palsy, whereas the lateral compartment was significantly smaller than the medial in anisotropic SO palsy (P = 0.01). In contrast to the SO, there were no differential compartmental volume changes in rectus EOMs; however, there was significant total muscle hypertrophy in the ipsilesional inferior rectus (IR) and lateral rectus (LR) muscles and contralesional superior rectus (SR) muscles. Medial rectus (MR) volume was normal both ipsi- and contralesionally.

conclusionsA subset of patients with SO palsy exhibit selective atrophy of the lateral, predominantly vertically acting SO compartment. Superior oblique atrophy is associated with whole-muscle volume changes in the ipsilesional IR, ipsilesional LR, and contralesional SR; however, SO muscle atrophy is not associated with compartmentally selective volume changes in the rectus EOMs. Selective compartmental SO pathology may provide an anatomic mechanism that explains some of the variability in clinical presentations of SO palsy.

Indexed as

AdolescentAdultAgedAtrophyEye MovementsFemaleFollow-Up StudiesHumansMagnetic Resonance ImagingMaleMiddle AgedOculomotor MusclesProspective StudiesTrochlear Nerve DiseasesYoung Adult

Identifiers

PMID27768791
PMCPMC5080936
OpenAlexW2542016358

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.