ArticlePLoS genetics2016
Genetic Dissection of Aversive Associative Olfactory Learning and Memory in Drosophila Larvae.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- Article
- No evidence for aversive associative olfactory memory through metamorphosis in Drosophila.Biology open · 2026Article
- Finding a path: local search behavior of Drosophila larvae.The Journal of experimental biology · 2025Article
- A pair of dopaminergic neurons DAN-c1 mediateeLife · 2025Article
- Article
- Article
- Energetic Demands Regulate Sleep-Wake Rhythm Circuit Development.bioRxiv : the preprint server for biology · 2024Article
- Cognitive limits of larvalLearning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Drosophila larvae form appetitive and aversive associative memory in response to thermal conditioning.PloS one · 2024Article
- Phenylacetaldehyde induced olfactory conditioning in Drosophila melanogaster (Diptera: Drosophilidae) larvae.Journal of insect science (Online) · 2023Article
- Rewarding Capacity of Optogenetically Activating a Giant GABAergic Central-Brain Interneuron in LarvalThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Developmental emergence of sleep rhythms enables long-term memory inScience advances · 2023Article
- Metamorphosis of memory circuits ineLife · 2023Article
- The function of ethanol in olfactory associative behaviors in Drosophila melanogaster larvae.PloS one · 2023Article
- Review
- Inherent constraints on a polyfunctional tissue lead to a reproduction-immunity tradeoff.BMC biology · 2022Article
- Optogenetic and thermogenetic manipulation of defined neural circuits and behaviors inLearning & memory (Cold Spring Harbor, N.Y.) · 2022Article
- Article
- Insulin signaling represents a gating mechanism between different memory phases in Drosophila larvae.PLoS genetics · 2020Article
- Identification of Dopaminergic Neurons That Can Both Establish Associative Memory and Acutely Terminate Its Behavioral Expression.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memory formation is a highly complex and dynamic process. It consists of different phases, which depend on various neuronal and molecular mechanisms. In adult Drosophila it was shown that memory formation after aversive Pavlovian conditioning includes-besides other forms-a labile short-term component that consolidates within hours to a longer-lasting memory. Accordingly, memory formation requires the timely controlled action of different neuronal circuits, neurotransmitters, neuromodulators and molecules that were initially identified by classical forward genetic approaches. Compared to adult Drosophila, memory formation was only sporadically analyzed at its larval stage. Here we deconstruct the larval mnemonic organization after aversive olfactory conditioning. We show that after odor-high salt conditioning larvae form two parallel memory phases; a short lasting component that depends on cyclic adenosine 3'5'-monophosphate (cAMP) signaling and synapsin gene function. In addition, we show for the first time for Drosophila larvae an anesthesia resistant component, which relies on radish and bruchpilot gene function, protein kinase C activity, requires presynaptic output of mushroom body Kenyon cells and dopamine function. Given the numerical simplicity of the larval nervous system this work offers a unique prospect for studying memory formation of defined specifications, at full-brain scope with single-cell, and single-synapse resolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.