ArticleJournal of the American Chemical Society2016
Self-Assembly of Catenanes from Lasso Peptides.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Chemoenzymatic Modification of Microcin J25 with Single-Residue Precision Provides New-to-Nature Lasso Peptides.JACS Au · 2026Article
- Tangled Tail of Mechanically Interlocked Peptides.Journal of the American Chemical Society · 2026Review
- Repositioning the Leader Peptide in Graspetide Biosynthesis.Journal of the American Chemical Society · 2026Article
- Expanding the Chemical Space of Mechanically Interlocked Peptides (MIPs) via Rational Design and Metabolite Profiling.JACS Au · 2025Article
- Embracing Complexity: Peptides as Tunable Scaffolds in the Construction of Discrete Supramolecular Systems.Angewandte Chemie (International ed. in English) · 2025Review
- LassoPred: a tool to predict the 3D structure of lasso peptides.Nature communications · 2025Article
- Switchable protection and exposure of a sensitive squaraine dye within a redox active rotaxane.Communications chemistry · 2024Article
- Cysteine Redox Chemistry in Peptide Self-Assembly to Modulate Hydrogelation.Molecules (Basel, Switzerland) · 2023Article
- A single-domain green fluorescent protein catenane.Nature communications · 2023Article
- Redox-Responsive Lipidic Prodrug Nano-Delivery System Improves Antitumor Effect of Curcumin Derivative C210.Pharmaceutics · 2023Article
- Lasso Proteins-Unifying Cysteine Knots and Miniproteins.Polymers · 2021Article
- Dynamic covalent self-assembly of mechanically interlocked molecules solely made from peptides.Nature chemistry · 2021Article
- Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides.Frontiers in bioengineering and biotechnology · 2021Review
- Heterologous production of new lasso peptide koreensin based on genome mining.The Journal of antibiotics · 2021Article
- How to harness biosynthetic gene clusters of lasso peptides.Journal of industrial microbiology & biotechnology · 2020Review
- Discovery of Ubonodin, an Antimicrobial Lasso Peptide Active against Members of the Burkholderia cepacia Complex.Chembiochem : a European journal of chemical biology · 2020Article
- Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications.ACS synthetic biology · 2019Article
- Statistical Properties of Lasso-Shape Polymers and Their Implications for Complex Lasso Proteins Function.Polymers · 2019Article
- Lasso Peptide Benenodin-1 Is a Thermally Actuated [1]Rotaxane Switch.Journal of the American Chemical Society · 2017Article
- Synthesis of spiro quasi[1]catenanes and quasi[1]rotaxanes via a templated backfolding strategy.Nature communications · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Lasso peptides exist naturally in a threaded state as [1]rotaxanes, and we reasoned that lasso peptides cleaved in their loop region could serve as building blocks for catenanes. Mutagenesis of the lasso peptide microcin J25 (MccJ25) with two cysteine residues followed by cleavage of the peptide with trypsin led to a [2]rotaxane structure that self-assembled into a [3]catenane and [4]catenanes at room temperature in aqueous solution. The [3]catenane represents the smallest ring size of a catenane composed solely of polypeptide segments. The NMR structure of the [3]catenane was determined, suggesting that burial of hydrophobic residues may be a driving force for assembly of the catenane structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.