Evidence map›Paper›PMID 27768124›Full record

ArticleCell death and differentiation2017

Neovascularization and functional recovery after intracerebral hemorrhage is conditioned by the Tp53 Arg72Pro single-nucleotide polymorphism.

Cristina Rodríguez, Tomás Sobrino, Jesús Agulla, Verónica Bobo-Jiménez, María E Ramos-Araque, Juan J Duarte, José C Gómez-Sánchez, Juan P Bolaños, José Castillo, Ángeles Almeida

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death and differentiation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Influences of genetic variants on stroke recovery: a meta-analysis of the 31,895 cases.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cristina RodríguezInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
Tomás SobrinoHealth Research Institute of Santiago de Compostela, University Clinical Hospital-University of Santiago de Compostela, A Coruña, Spain.
Jesús AgullaInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
Verónica Bobo-JiménezInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
María E Ramos-AraqueInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
Juan J DuarteInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
José C Gómez-SánchezInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
Juan P BolañosInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
José CastilloHealth Research Institute of Santiago de Compostela, University Clinical Hospital-University of Santiago de Compostela, A Coruña, Spain.
Ángeles AlmeidaInstitute of Biomedical Research of Salamanca, University Hospital of Salamanca-University of Salamanca, Salamanca, Spain.
Instituto de Biología Funcional y Genómica · ESUniversidad de Salamanca · ESUniversidade de Santiago de Compostela · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intracerebral hemorrhage (ICH) is a devastating subtype of stroke that lacks effective therapy and reliable prognosis. Neovascularization following ICH is an essential compensatory response that mediates brain repair and modulates the clinical outcome of stroke patients. However, the mechanism that dictates this process is unknown. Bone marrow-derived endothelial progenitor cells (EPCs) promote endothelial repair and contribute to ischemia-induced neovascularization. The human Tp53 gene harbors a common single-nucleotide polymorphism (SNP) at codon 72, which yields an arginine-to-proline amino-acidic substitution (Arg72Pro) that modulates the apoptotic activity of the p53 protein. Previously, we found that this SNP controls neuronal susceptibility to ischemia-induced apoptosis in vitro. Here, we evaluated the impact of the Tp53 Arg72Pro SNP on vascular repair and functional recovery after ICH. We first analyzed EPC mobilization and functional outcome based on the modified Rankin scale scores in a hospital-based cohort of 78 patients with non-traumatic ICH. Patients harboring the Pro allele of the Tp53 Arg72Pro SNP showed higher levels of circulating EPC-containing CD34

Indexed as

Neovascularization, PhysiologicAgedAged, 80 and overAnimalsApoptosisArginineBone Marrow CellsBrainCells, CulturedCerebral HemorrhageChemokine CXCL12CollagenasesDisease Models, AnimalEndothelial Progenitor CellsFemaleHumansArginineChemokine CXCL12CollagenasesProlineTumor Suppressor Protein p53Vascular Endothelial Growth Factor A

Identifiers

PMID27768124
PMCPMC5260494
OpenAlexW2538759350

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.