ArticleJournal of visualized experiments : JoVE2016
Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction.
Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Establishment of an MR-Conditional Porcine Model for Real-Time Assessment of Cerebral Blood Flow During Extracorporeal Circulation.Journal of cardiovascular development and disease · 2026Article
- Improved methodology for efficient establishment of the myocardial ischemia-reperfusion model in pigs through the median thoracic incision.Journal of biomedical research · 2023Article
- Molecular Network Approach RevealsInternational journal of molecular sciences · 2021Article
- Transesophageal echocardiography in swine: evaluation of left and right ventricular structure, function and myocardial work.The international journal of cardiovascular imaging · 2021Article
- Neutral Effects of Combined Treatment With GLP-1R Agonist Exenatide and MR Antagonist Potassium Canrenoate on Cardiac Function in Porcine and Murine Chronic Heart Failure Models.Frontiers in pharmacology · 2021Article
- Loop analysis of the anal sphincter complex in fecal incontinent patients using functional luminal imaging probe.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Evaluating Novel Targets of Ischemia Reperfusion Injury in Pig Models.International journal of molecular sciences · 2019Review
- Feasibility of basic transesophageal echocardiography in hemorrhagic shock: potential applications during resuscitative endovascular balloon occlusion of the aorta (REBOA).Cardiovascular ultrasound · 2018Article
- Improvement of a Closed Chest Porcine Myocardial Infarction Model by Standardization of Tissue and Blood Sampling Procedures.Journal of visualized experiments : JoVE · 2018Article
- Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine.Journal of visualized experiments : JoVE · 2018Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mortality after acute myocardial infarction remains substantial and is associated with significant morbidity, like heart failure. Novel therapeutics are therefore required to confine cardiac damage, promote survival and reduce the disease burden of heart failure. Large animal experiments are an essential part in the translational process from experimental to clinical therapies. To optimize clinical translation, robust and representative outcome measures are mandatory. The present manuscript aims to address this need by describing the assessment of three clinically relevant outcome modalities in a pig acute myocardial infarction (AMI) model: infarct size in relation to area at risk (IS/AAR) staining, 3-dimensional transesophageal echocardiography (TEE) and admittance-based pressure-volume (PV) loops. Infarct size is the main determinant driving the transition from AMI to heart failure and can be quantified by IS/AAR staining. Echocardiography is a reliable and robust tool in the assessment of global and regional cardiac function in clinical cardiology. Here, a method for three-dimensional transesophageal echocardiography (3D-TEE) in pigs is provided. Extensive insight into cardiac performance can be obtained by admittance-based pressure-volume (PV) loops, including intrinsic parameters of myocardial function that are pre- and afterload independent. Combined with a clinically feasible experimental study protocol, these outcome measures provide researchers with essential information to determine whether novel therapeutic strategies could yield promising targets for future testing in clinical studies.
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