Evidence map›Paper›PMID 27768025›Full record

ArticleJournal of visualized experiments : JoVE2016

Rapid Scan Electron Paramagnetic Resonance Opens New Avenues for Imaging Physiologically Important Parameters In Vivo.

Joshua R Biller, Deborah G Mitchell, Mark Tseytlin, Hanan Elajaili, George A Rinard, Richard W Quine, Sandra S Eaton, Gareth R Eaton

Open access · bronzeAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of visualized experiments : JoVE, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Computationally efficient 4D spectral-spatial EPR imaging.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2025
    Article
  2. Article
  3. Rapid scan EPR: Automated digital resonator control for low-latency data acquisition.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2022
    Article
  4. EPR Everywhere.Applied magnetic resonance · 2021
    Review
  5. Article
  6. Article
  7. Full cycle rapid scan EPR deconvolution algorithm.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2017
    Article
  8. Medical gas research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Joshua R BillerDepartment of Chemistry and Biochemistry, University of Denver; Magnetic Imaging Group, Applied Physics Division, Physical Measurements Laboratory, National Institute of Standards and Technology.
Deborah G MitchellDepartment of Chemistry and Biochemistry, University of Denver.
Mark TseytlinDepartment of Radiology, Geisel School of Medicine, Dartmouth University; Department of Biochemistry, West Virginia University.
Hanan ElajailiDepartment of Chemistry and Biochemistry, University of Denver.
George A RinardDepartment of Electrical and Computer Engineering, University of Denver.
Richard W QuineDepartment of Engineering, University of Denver.
Sandra S EatonDepartment of Chemistry and Biochemistry, University of Denver.
Gareth R EatonDepartment of Chemistry and Biochemistry, University of Denver; gareth.eaton@du.edu.
University of Denver · USDartmouth College · USPhysical Measurement Laboratory · US

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
Very Low Frequency EPR Imaging in Vivo Phisiology P41 EB02034P41EB002034 · NIBIB · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2017
$16.1M
Radiation Biology of EPR Oxygen ImagesR01CA098575 · NCI · UNIVERSITY OF CHICAGO · PI HALPERN, HOWARD J · 2003 to 2022
$4.5M
Preclinical Electron Paramagnetic Resonance Tumor ImagerR01CA177744 · NCI · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, GARETH R · 2014 to 2019
$2.7M
INTERACTION OF SPIN LABELS WITH TRANSITION METALSR01EB002807 · NIBIB · UNIVERSITY OF DENVER (COLORADO SEMINARY) · PI EATON, GARETH R · 2003 to 2008
$1.9M
Multifunctional in Vivo EPR Imaging of Tumor MicroenvironmentR21EB022775 · NIBIB · WEST VIRGINIA UNIVERSITY · PI TSEYTLIN, MARK · 2016 to 2017
$427k
Enhancing in vivo EPR imaging using spin probes with short relaxation timesK25EB016040 · NIBIB · WEST VIRGINIA UNIVERSITY · PI TSEYTLIN, MARK · 2013 to 2015
$416k
NCI NIH HHS R01 CA098575NCI NIH HHS R01 CA177744NIBIB NIH HHS K25 EB016040NIBIB NIH HHS P41 EB002034NIBIB NIH HHS R01 EB002807NIBIB NIH HHS R21 EB022775NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

We demonstrate a superior method of 2D spectral-spatial imaging of stable radical reporter molecules at 250 MHz using rapid-scan electron-paramagnetic-resonance (RS-EPR), which can provide quantitative information under in vivo conditions on oxygen concentration, pH, redox status and concentration of signaling molecules (i.e., OH

Indexed as

Electron Spin Resonance SpectroscopySignal TransductionHydrogen-Ion ConcentrationOxidation-ReductionOxygenPhantoms, ImagingRadionuclide ImagingOxygen

Identifiers

PMID27768025
PMCPMC5092072
OpenAlexW2523959356

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.