Evidence map›Paper›PMID 27767358›Full record

ArticleRenal failure2017

Urinary l-type fatty acid-binding protein is a predictor of early renal function after partial nephrectomy.

Masaaki Yanishi, Hidefumi Kinoshita, Takao Mishima, Hisanori Taniguchi, Kenji Yoshida, Yoshihiro Komai, Kaneki Yasuda, Masato Watanabe, Motohiko Sugi, Tadashi Matsuda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Role of the Furosemide Stress Test in Renal Injury Prognosis.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Masaaki Yanishia Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Hidefumi Kinoshitaa Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Takao Mishimaa Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Hisanori Taniguchia Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Kenji Yoshidaa Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Yoshihiro Komaia Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Kaneki Yasudaa Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Masato Watanabea Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Motohiko Sugia Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.
Tadashi Matsudaa Department of Urology and Andrology, Graduate School of Medicine , Kansai Medical University , Osaka , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUrinary biomarkers of renal injury urinary may identify loss of renal function following nephron-sparing surgery (NSS). This study was designed to evaluate whether urinary l-type fatty acid-binding protein (l-FABP) is an early biomarker of loss of renal function after NSS. Specifically, the kinetics of urinary l-FABP level after NSS and its correlation with factors related to ischemic renal injury were analyzed.

methodsThis study prospectively evaluated 18 patients who underwent NSS between July and December 2014, including 12 who underwent laparoscopic and six who underwent robot-assisted partial nephrectomy. Urinary l-FABP concentrations were measured preoperatively and 1, 2, 3, 6, 12, 24, 48, and 72 h after renal artery declamping. Loss of renal function loss was calculated by comparing the effective renal plasma flow, as determined by

resultsUrinary l-FABP concentration peaked within 2 h of declamping, which may quantify nephron damage caused by ischemia. The decrease in MAG3 reduction ratio correlated with both the ischemia time and peak urinary l-FABP concentration. Peak urinary l-FABP concentration showed a significant correlation with MAG3 reduction ratio.

conclusionsl-FABP is a suitable urinary biomarker for predicting the extent of ischemic renal injury.

Indexed as

AdultAgedAged, 80 and overBiomarkersFatty Acid-Binding ProteinsFemaleHumansIschemiaJapanKidney Function TestsLaparoscopyLinear ModelsMaleMiddle AgedNephrectomyNephronsBiomarkersFatty Acid-Binding Proteinsl-Type fatty acid-binding proteinpartial nephrectomyrenal functionrenal injuryurinary biomarker

Identifiers

PMID27767358
PMCPMC6014395

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.