ArticleJournal of clinical periodontology2017
Long-term clinical response to treatment and maintenance of localized aggressive periodontitis: a cohort study.
Article in Journal of clinical periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01330719 (Mechanisms and Treatment Response of Aggressive Periodontitis in Children), which is not on this map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mechanisms and Treatment Response of Aggressive Periodontitis in Children: Aberrant Immunological Phenotypes/Functions in the Progression of AgP
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Non-Surgical Therapy Reduces Presence of JP2 Clone in Localized Aggressive Periodontitis.Journal of periodontology · 2017Trial
- Grade C molar-incisor pattern periodontitis classification and its challenges.Journal of periodontology · 2026Review
- The Evolution of Prepubertal Localized Aggressive Periodontitis in Primary and Mixed Dentition-Clinical Evidence.Journal of clinical medicine · 2026Article
- Molar-Incisor and Generalized Grade C Periodontitis: Distinct Microbiome-Immune Interactions Suggest Divergent Pathogenesis.Journal of periodontal research · 2026Article
- Harnessing ultrasound-responsive technologies for precision periodontitis therapy: a perspective.Theranostics · 2026Review
- Gingival Crevicular Fluid Biomarkers During Periodontitis Progression and After Periodontal Treatment.Journal of clinical periodontology · 2025Article
- Salivary and serum inflammatory biomarkers during periodontitis progression and after treatment.Journal of clinical periodontology · 2024Article
- Association of RS1126478 (LTF) with molar-incisor and generalized periodontitis.Clinical oral investigations · 2024Article
- A Rose by Any Other Name: The Long Intricate History of Localized Aggressive Periodontitis.Pathogens (Basel, Switzerland) · 2024Review
- Grade C Molar-Incisor Pattern Periodontitis in Young Adults: What Have We Learned So Far?Pathogens (Basel, Switzerland) · 2024Review
- Periodontal inflammatory and microbial profiles in healthy young African Americans and Caucasians.Journal of clinical periodontology · 2024Article
- Evaluation of microbiome in primary and permanent dentition in grade C periodontitis in young individuals.Journal of periodontology · 2024Article
- A Modern Approach to Treat Molar/Incisor Pattern Periodontitis-Review.Journal of clinical medicine · 2023Review
- Treatment of Periodontitis Affecting Human Primary Teeth-A Systematic Review.Dentistry journal · 2023Review
- Impact of Treatment on Host Responses in Young Individuals with Periodontitis.Journal of dental research · 2023Review
- Gender differences in immunological response of African-American juveniles with Grade C molar incisor pattern periodontitis.Journal of periodontology · 2022Article
- In vitro evaluation of physical and chemical parameters involved in aPDT of Aggregatibacter actinomycetemcomitans.Lasers in medical science · 2022Article
- Aggregatibacter actinomycetemcomitans: From Basic to Advanced Research.Advances in experimental medicine and biology · 2022Article
- Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation.Journal of clinical periodontology · 2021Article
- Periodontal Regeneration with Enamel Matrix Derivative in the Management of Generalized Aggressive Periodontitis: A Case Report with 11-Year Follow-up and Literature Review.Journal of International Society of Preventive & Community DentistryReview
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Authors and funding
9 authors at 2 institutions in 4 countries.
Funding
Abstract
aimTo evaluate long-term clinical response to periodontal therapy and maintenance in localized aggressive periodontitis (LAP). MATERIALS AND
methodsOne hundred forty-one African Americans diagnosed with LAP, aged 5-25 years, were enrolled. Patients underwent periodontal mechanical debridement plus 1 week of amoxicillin/metronidazole. Mechanical therapy was repeated as needed and clinical parameters were recorded at baseline, 3, 6, 12, 18 and 24 months, and two additional annual follow-up visits after treatment. Radiographs from primary dentition of patients with LAP in permanent dentition, and additional healthy siblings (HS) were analysed retrospectively.
resultsPeriodontal therapy significantly improved probing depth and clinical attachment level up to 4 years (mean reductions: 2.18 ± 1.03 and 2.80 ± 1.43 mm, respectively). Percentage of affected sites was reduced at all time points and maintained up to 4 years. Non-compliance with antibiotics/appointments negatively affected the treatment response. Ninety per cent of LAP patients in permanent dentition and 32% of HS presented radiographic bone loss in primary dentition.
conclusionsMechanical debridement with 1 week of systemic antibiotics along with proper periodontal maintenance was effective in the treatment and successful maintenance of LAP for up to 4 years. LAP in permanent dentition may be preceded in the primary dentition. Clinicaltrials.gov #NCT01330719.
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