ArticleScientific reports2016
Alteration of blood clot structures by interleukin-1 beta in association with bone defects healing.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
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- Immunomodulation Using BMP-7 and IL-10 to Enhance the Mineralization Capacity of Bone Progenitor Cells in a Fracture Hematoma-Like Environment.Advanced healthcare materials · 2025Article
- Near-Infrared Spectroscopy Allows for Monitoring of Bone Fracture Healing via Changes in Oxygenation.Journal of functional biomaterials · 2024Article
- Unravelling the Antifibrinolytic Mechanism of Action of the 1,2,3-Triazole Derivatives.International journal of molecular sciences · 2024Article
- Blood Clotting Dissolution in the Presence of a Magnetic Field and Preliminary Study with MG63 Osteoblast-like Cells-Further Developments for Guided Bone Regeneration?Bioengineering (Basel, Switzerland) · 2023Article
- Microporous/Macroporous Polycaprolactone Scaffolds for Dental Applications.Pharmaceutics · 2023Article
- IL-1β contributes to the secretion of sclerostin by osteocytes and targeting sclerostin promotes spinal fusion at early stages.Journal of orthopaedic surgery and research · 2023Article
- Titanium surface interacting with blood clot enhanced migration and osteogenic differentiation of bone marrow mesenchymal stem cells.Frontiers in bioengineering and biotechnology · 2023Article
- Polyphosphate-crosslinked collagen scaffolds for hemostasis and alveolar bone regeneration after tooth extraction.Bioactive materials · 2022Article
- Inflammasomes and the IL-1 Family in Bone Homeostasis and Disease.Current osteoporosis reports · 2022Review
- Mesopore Controls the Responses of Blood Clot-Immune Complex via Modulating Fibrin Network.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Surface engineering of titania nanotubes incorporated with double-layered extracellular vesicles to modulate inflammation and osteogenesis.Regenerative biomaterials · 2021Article
- Cytokine "fine tuning" of enthesis tissue homeostasis as a pointer to spondyloarthritis pathogenesis with a focus on relevant TNF and IL-17 targeted therapies.Seminars in immunopathology · 2021Review
- Modulatory Role of Silver Nanoparticles and Mesenchymal Stem Cell-Derived Exosome-Modified Barrier Membrane on Macrophages and Osteogenesis.Frontiers in chemistry · 2021Article
- Article
- Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation.Blood advances · 2020Article
- Nanomaterial Nitric Oxide Delivery in Traumatic Orthopedic Regenerative Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- Osteoimmune Modulation and Guided Osteogenesis Promoted by Barrier Membranes Incorporated with S-Nitrosoglutathione (GSNO) and Mesenchymal Stem Cell-Derived Exosomes.International journal of nanomedicine · 2020Article
- Transcriptional profiling of intramembranous and endochondral ossification after fracture in mice.Bone · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The quality of hematomas are crucial for successful early bone defect healing, as the structure of fibrin clots can significantly influence the infiltration of cells, necessary for bone regeneration, from adjacent tissues into the fibrin network. This study investigated if there were structural differences between hematomas from normal and delayed healing bone defects and whether such differences were linked to changes in the expression of IL-1β. Using a bone defect model in rats, we found that the hematomas in the delayed healing model had thinner fibers and denser clot structures. Moreover, IL-1β protein levels were significantly higher in the delayed healing hematomas. The effects of IL-1β on the structural properties of human whole blood clots were evaluated by thrombelastograph (TEG), scanning electronic microscopy (SEM), compressive study, and thrombolytic assays. S-nitrosoglutathione (GSNO) was applied to modulate de novo hematoma structure and the impact on bone healing was evaluated in the delayed healing model. We found that GSNO produced more porous hematomas with thicker fibers and resulted in significantly enhanced bone healing. This study demonstrated that IL-1β and GSNO had opposing effects on clot architecture, the structure of which plays a pivotal role in early bone healing.
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