ArticleEmerging infectious diseases2016
Reassortant Eurasian Avian-Like Influenza A(H1N1) Virus from a Severely Ill Child, Hunan Province, China, 2015.
Article in Emerging infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 52 citations in OpenAlex.
- Genetic Characteristics and Pathogenicity of Recent G4 Eurasian Avian-like H1N1 Swine Influenza Viruses in China.Veterinary sciences · 2026Article
- Diverse genomic landscape of swine influenza A virus in England (2014-2021).Microbial genomics · 2026Article
- Article
- Cases of Interspecies Transmission of Influenza A Virus from Swine to Humans.Veterinary sciences · 2025Review
- Glutamic Acid at Position 343 in PB2 Contributes to the Virulence of H1N1 Swine Influenza Virus in Mice.Viruses · 2025Article
- Evaluation of pandemic potential of the genotype 4 (G4) swine influenza virus usingThe Journal of general virology · 2025Article
- Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice.Journal of virology · 2024Article
- Emergence of Eurasian Avian-Like Swine Influenza A (H1N1) virus in a child in Shandong Province, China.BMC infectious diseases · 2024Article
- Interspecies Transmission of Swine Influenza A Viruses and Human Seasonal Vaccine-Mediated Protection Investigated in Ferret Model.Emerging infectious diseases · 2023Article
- Continued evolution of the Eurasian avian-like H1N1 swine influenza viruses in China.Science China. Life sciences · 2023Article
- Genetic characterization and pathogenicity of a Eurasian avian-like H1N1 swine influenza reassortant virus.Virology journal · 2022Article
- Immune Escape Adaptive Mutations in Hemagglutinin Are Responsible for the Antigenic Drift of Eurasian Avian-Like H1N1 Swine Influenza Viruses.Journal of virology · 2022Article
- A Eurasian avian-like H1N1 swine influenza reassortant virus became pathogenic and highly transmissible due to mutations in its PA gene.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus.Virologica Sinica · 2022Article
- Potential Threats to Human Health from Eurasian Avian-Like Swine Influenza A(H1N1) Virus and Its Reassortants.Emerging infectious diseases · 2022Article
- Are pigs overestimated as a source of zoonotic influenza viruses?Porcine health management · 2022Review
- Determining Existing Human Population Immunity as Part of Assessing Influenza Pandemic Risk.Emerging infectious diseases · 2022Article
- Human infection with a reassortant swine-origin influenza A(H1N2)v virus in Taiwan, 2021.Virology journal · 2022Article
- Evolution of influenza A virus in intensive and free-range swine farms in Spain.Virus evolution · 2022Article
- Serological Surveillance of the H1N1 and H3N2 Swine Influenza A Virus in Chinese Swine between 2016 and 2021.BioMed research international · 2022Article
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Authors and funding
20 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In 2015, a novel influenza A(H1N1) virus was isolated from a boy in China who had severe pneumonia. The virus was a genetic reassortant of Eurasian avian-like influenza A(H1N1) (EA-H1N1) virus. The hemagglutinin, neuraminidase, and matrix genes of the reassortant virus were highly similar to genes in EA-H1N1 swine influenza viruses, the polybasic 1 and 2, polymerase acidic, and nucleoprotein genes originated from influenza A(H1N1)pdm09 virus, and the nonstructural protein gene derived from classical swine influenza A(H1N1) (CS H1N1) virus. In a mouse model, the reassortant virus, termed influenza A/Hunan/42443/2015(H1N1) virus, showed higher infectivity and virulence than another human EA-H1N1 isolate, influenza A/Jiangsu/1/2011(H1N1) virus. In the respiratory tract of mice, virus replication by influenza A/Hunan/42443/2015(H1N1) virus was substantially higher than that by influenza A/Jiangsu/1/2011(H1N1) virus. Human-to-human transmission of influenza A/Hunan/42443/2015(H1N1) virus has not been detected; however, given the circulation of novel EA-H1N1 viruses in pigs, enhanced surveillance should be instituted among swine and humans.
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