ReviewClinical and translational medicine2016
Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation.
Review in Clinical and translational medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Clinical translation of stem cell therapy for spinal cord injury still premature: results from a single-arm meta-analysis based on 62 clinical trials.BMC medicine · 2022Pooled it
- Article
- Article
- Advances in the clinical application of orthotic devices for stroke and spinal cord injury since 2013.Frontiers in neurology · 2023Review
- Article
- Current progress of rehabilitative strategies in stem cell therapy for spinal cord injury: a review.NPJ Regenerative medicine · 2021Review
- Tissue-Engineered Neural Network Graft Relays Excitatory Signal in the Completely Transected Canine Spinal Cord.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
- Review of the Current Knowledge on the Role of Stem Cell Transplantation in Neurorehabilitation.BioMed research international · 2019Review
- Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration.International journal of molecular medicine · 2018Article
- Expression of Concern to: Role of physiotherapy in the mobilization of patients with spinal cord injury undergoing human embryonic stem cells transplantation.Clinical and translational medicine · 2017Article
Corrections and comments
- Expression of concern · 2017-09-18Author Unresponsive · Concerns/Issues about Data · Concerns/Issues about Results and/or Conclusions · Investigation by Journal/Publisher ·
- Expression of concern
Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe major complication faced by patients with chronic static spinal cord injury (SCI) is the loss of mobilization. With the aim to rehabilitate SCI patients, physiotherapy is performed worldwide. However, it only helps the patients to live with their disabilities. An interdisciplinary management involving human embryonic stem cell (hESC) therapy along with physiotherapy as a supportive therapy offers regenerative treatment of the patients with SCI. MAIN BODY: The present study focuses on the role of physiotherapy in the mobilization of patients with SCI (paraplegic 136; tetraplegics 90) undergoing hESC therapy. At admission, patients were assessed on the basis of clinical and American Spinal Injury Association Impairment Scale (AIS), where 153, 32, 36 and 5 patients were designated with AIS score A, B, C and D, respectively. After 8-12 weeks of hESC therapy and physiotherapy, the patients showed clinical and scoring improvement. The patients with AIS score A shifted to B (15.0 %) and C (37.3 %), whereas, patients with grade B moved to C (40.6 %) and D (3.1 %). Patients with AIS score C and D shifted to grade D (13.9 %) and E (60.0 %), respectively. Moreover, orthotic devices were reduced to simpler ones.
conclusionThe physiotherapy aided in training of cells and took care of atrophy of limbs, whereas hESC therapy resulted in an overall improvement of the patients with SCI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.