Evidence map›Paper›PMID 27766537›Full record

ArticleMolecular neurobiology2017

A Novel Bioresorbable Device as a Controlled Release System for Protecting Cells from Oxidative Stress from Alzheimer's Disease.

Geisa Nogueira Salles, Fernanda Aparecida Dos Santos Pereira, Cristina Pacheco-Soares, Fernanda Roberta Marciano, Christian Hölscher, Thomas J Webster, Anderson Oliveira Lobo

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Geisa Nogueira SallesLaboratory of Biomedical Nanotechnology, Institute of Research and Development (IP&D), University of Vale do Paraiba (UNIVAP), São Jose dos Campos, São Paulo, 12244-000, Brazil.
Fernanda Aparecida Dos Santos PereiraLaboratory of Biomedical Nanotechnology, Institute of Research and Development (IP&D), University of Vale do Paraiba (UNIVAP), São Jose dos Campos, São Paulo, 12244-000, Brazil.
Cristina Pacheco-SoaresLaboratory of Dynamics of Cellular Compartments, IP&D, University of Vale do Paraíba (Univap), São Jose dos Campos, São Paulo, 12244-000, Brazil.
Fernanda Roberta MarcianoLaboratory of Biomedical Nanotechnology, Institute of Research and Development (IP&D), University of Vale do Paraiba (UNIVAP), São Jose dos Campos, São Paulo, 12244-000, Brazil.
Christian HölscherDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, LA1 4YQ, England.
Thomas J WebsterDepartment of Chemical Engineering, Northeastern University, Boston, MA, 02115, USA.
Anderson Oliveira LoboLaboratory of Biomedical Nanotechnology, Institute of Research and Development (IP&D), University of Vale do Paraiba (UNIVAP), São Jose dos Campos, São Paulo, 12244-000, Brazil. lobo.aol@gmail.com.
Universidade do Vale do Paraíba · BRBrigham and Women's Hospital · USInnovation Research Center · USLancaster University · GBNortheastern University · US

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 474090/2013-2Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.095044/2015-00Financiadora de Estudos e Projetos 0113042800Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/17877-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2011/20345-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2014/20561-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2015/09697-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/00575-1
6 · The paper itself

Abstract

Bioresorbable electrospun fibres have highly functional features that can preserve drug efficacy, avoiding premature degradation, and control drug release rates over long periods. In parallel, it is known that Alzheimer's disease (AD) has been linked to impaired insulin signalling in the brain. Glucagon-like peptide 1 (GLP-1) analogues have beneficial effects on insulin release and possess exceptional neuroprotective properties. Herein, we describe for the first time the incorporation of a GLP-1 analogue, liraglutide, into electrospun poly (lactic acid) (PLA) fibres with in situ gelatin capsules, in order to provide the controlled release of liraglutide, improving neuroprotective properties. In this study, PLA, a bioresorbable polymer in which degradation products have neurogenesis characteristics, was electrospun and loaded with liraglutide. Moreover, PLA/liraglutide fibres were encapsulated with gelatin and were shown to have better properties than the non-encapsulated fibres in terms of the controlled release of liraglutide, which was accomplished in the present study for up to 60 days. We observed that this biodevice was completely encapsulated with gelatin, which made the material more hydrophilic than PLA fibres alone and the biodevice was able to enhance fibroblast interaction and reduce mitochondrial stress in a neuroblastoma cell line. In this manner, this study introduces a new material which can improve neuroprotective properties from AD oxidative stress via the sustained long-lasting release of liraglutide. Graphical Abstract ᅟ.

Indexed as

Absorbable ImplantsAlzheimer DiseaseAnimalsCell Line, TumorCytoprotectionDelayed-Action PreparationsFibroblastsHumansLiraglutideMiceOxidative StressPolyestersDelayed-Action PreparationsLiraglutidePolyesterspoly(lactide)Alzheimer’s diseaseBiodeviceDrug deliveryElectrospun fibresLiraglutidePolyesterSustained release

Identifiers

PMID27766537
OpenAlexW2535480558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.