ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2017
Proxy-reported quality of life in adolescents and adults with dyskinetic cerebral palsy is associated with executive functions and cortical thickness.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Interventions with an Impact on Cognitive Functions in Cerebral Palsy: a Systematic Review.Neuropsychology review · 2023Pooled it
- Transferability of an executive function intervention in children with cerebral palsy: A randomized controlled trial.Developmental medicine and child neurology · 2025Trial
- Understanding social cognition in children with cerebral palsy: exploring the relationship with executive functions and the intervention outcomes in a randomized controlled trial.European journal of pediatrics · 2024Trial
- Inter-Individual Variability of Executive Functioning: a Possible Key to Understand Adaptive Behavior Across ASD and ADHD.Child psychiatry and human development · 2026Article
- Prematurity and autism: a dose-response relationship across gestational age.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Effects of Difficulties in Executive Functions on Behavioral and Adaptive Problems in Italian Autistic Preschoolers.Clinical neuropsychiatry · 2024Article
- A Virtual Reality Platform for Evaluating Deficits in Executive Functions in Deaf and Hard of Hearing Children-Relation to Daily Function and to Quality of Life.Children (Basel, Switzerland) · 2024Article
- Exploring early life social and executive function development in infants and risk for autism: a prospective cohort study protocol of NICU graduates and infants at risk for cerebral palsy.BMC psychiatry · 2024Article
- Article
- White matter microstructure and receptive vocabulary in children with cerebral palsy: The role of interhemispheric connectivity.PloS one · 2023Article
- Article
- Exploring the quality of life of adolescents with Cerebral Palsy participating in conductive education around the Pannonian Basin.PloS one · 2022Article
- How is quality of life defined and assessed in published research?Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Review
- Development and sensibility assessment of a health-related quality of life instrument for adults with severe disabilities who are non-ambulatory.Journal of applied research in intellectual disabilities : JARID · 2021Article
- Robotic-assisted cortical bone trajectory (CBT) screws using the Mazor X Stealth Edition (MXSE) system: workflow and technical tips for safe and efficient use.Journal of robotic surgery · 2021Review
- Study protocol of a randomized controlled trial of home-based computerized executive function training for children with cerebral palsy.BMC pediatrics · 2020Article
- Brain lesion scores obtained using a simple semi-quantitative scale from MR imaging are associated with motor function, communication and cognition in dyskinetic cerebral palsy.NeuroImage. Clinical · 2018Article
- How Executive Functions Are Evaluated in Children and Adolescents with Cerebral Palsy? A Systematic Review.Frontiers in psychology · 2018Article
- White matter integrity in dyskinetic cerebral palsy: Relationship with intelligence quotient and executive function.NeuroImage. Clinical · 2017Article
Corrections and comments
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Authors and funding
13 authors at 8 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeQuality of life (QOL) is a key outcome for people with cerebral palsy (CP), and executive functioning is an important predictor of QOL in other health-related conditions. Little is known about this association in CP or about its neural substrate. We aim to analyze the influence of executive functioning (including cognitive flexibility) as well as that of other psychological, motor, communication and socioeconomic variables on QOL and to identify neuroanatomical areas related to QOL in adolescents and adults with CP.
methodsFifty subjects diagnosed with dyskinetic CP (mean age 25.96 years) were recruited. Their caregivers completed the primary caregiver proxy report version of the CP QOL-Teen questionnaire. Motor status, communication, IQ, four executive function domains, anxiety/depression and socioeconomic status were evaluated. Correlations and multiple linear regression models were used to relate CP QOL domains and total score to these variables. Thirty-six participants underwent an MRI assessment. Correlations were examined between cortical thickness and CP QOL total score and between cortical thickness and variables that might predict the CP QOL total score.
resultsExecutive functions predict scores in four domains of CP QOL (General well-being and participation, Communication and physical health, Family health and Feelings about functioning) in the regression model. Among the cognitive domains that comprise executive function, only cognitive flexibility measured in terms of performance on the Wisconsin card sorting test (WCST) predicts the CP QOL total score. Monthly income, fine motor functioning and communication ability predict scores on the domains Access to services and Family Health, Feelings about functioning and School well-being, respectively. The clusters resulting from the correlation between cortical thickness and both CP QOL total score and WCST performance overlapped in the posterior cingulate and precuneus cortices.
conclusionsCognitive flexibility predicts proxy report CP QOL-Teen total score in dyskinetic CP. This relationship has its anatomical correlate in the posterior cingulate and precuneus cortices.
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