ArticleNeuroImage. Clinical2016
A negative relationship between ventral striatal loss anticipation response and impulsivity in borderline personality disorder.
Article in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Pooled it
- Parsing variability in borderline personality disorder: a meta-analysis of neuroimaging studies.Translational psychiatry · 2021Pooled it
- Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies.PloS one · 2021Pooled it
- Love is analogous to money in human brain: Coordinate-based and functional connectivity meta-analyses of social and monetary reward anticipation.Neuroscience and biobehavioral reviews · 2019Pooled it
- Specific frontostriatal structural alterations underlie emotional instability but not inattention in ADHD and healthy individuals.Journal of psychiatry & neuroscience : JPN · 2026Article
- Atypical reward anticipation in impulsive individuals: evidence from EEG and experiential delay discounting.Frontiers in psychology · 2025Article
- Interaction between emotion lability, emotion regulation and structural brain abnormalities in patients with anorexia nervosa and borderline personality disorder.Frontiers in neuroscience · 2025Article
- Stress and reward in the maternal brain of mothers with borderline personality disorder: a script-based fMRI study.European archives of psychiatry and clinical neuroscience · 2024Article
- Presentation and Management of Acute Mania in Fanconi-Bickel Syndrome, A Metabolic Genetic Disorder.Case reports in psychiatry · 2024Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
- A neuro-computational social learning framework to facilitate transdiagnostic classification and treatment across psychiatric disorders.Neuroscience and biobehavioral reviews · 2023Review
- Simultaneous EEG-fMRI reveals theta network alterations during reward feedback processing in borderline personality disorder.Scientific reports · 2021Article
- Impulsivity and Emotional Dysregulation Predict Choice Behavior During a Mixed-Strategy Game in Adolescents With Borderline Personality Disorder.Frontiers in neuroscience · 2021Article
- Striatal bases of temporal discounting in early adolescents.Neuropsychologia · 2020Article
- Toward an animal model of borderline personality disorder.Psychopharmacology · 2019Review
- Nonsuicidal Self-Injury and Suicidal Behaviors in Girls: The Case for Targeted Prevention in Preadolescence.Clinical psychological science : a journal of the Association for Psychological Science · 2019Article
- Gradual acquisition of visuospatial associative memory representations via the dorsal precuneus.Human brain mapping · 2019Article
- The Degree of Modulation of Beta Band Activity During Motor Planning Is Related to Trait Impulsivity.Frontiers in integrative neuroscience · 2019Article
- Physical pain recruits the nucleus accumbens during social distress in borderline personality disorder.Social cognitive and affective neuroscience · 2018Article
- Loss anticipation and outcome during thePeerJ · 2018Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
Patients with borderline personality disorder (BPD) frequently exhibit impulsive behavior, and self-reported impulsivity is typically higher in BPD patients when compared to healthy controls. Previous functional neuroimaging studies have suggested a link between impulsivity, the ventral striatal response to reward anticipation, and prediction errors. Here we investigated the striatal neural response to monetary gain and loss anticipation and their relationship with impulsivity in 21 female BPD patients and 23 age-matched female healthy controls using functional magnetic resonance imaging (fMRI). Participants performed a delayed monetary incentive task in which three categories of objects predicted a potential gain, loss, or neutral outcome. Impulsivity was assessed using the Barratt Impulsiveness Scale (BIS-11). Compared to healthy controls, BPD patients exhibited significantly reduced fMRI responses of the ventral striatum/nucleus accumbens (VS/NAcc) to both reward-predicting and loss-predicting cues. BIS-11 scores showed a significant positive correlation with the VS/NAcc reward anticipation responses in healthy controls, and this correlation, while also nominally positive, failed to reach significance in BPD patients. BPD patients, on the other hand, exhibited a significantly negative correlation between ventral striatal loss anticipation responses and BIS-11 scores, whereas this correlation was significantly positive in healthy controls. Our results suggest that patients with BPD show attenuated anticipation responses in the VS/NAcc and, furthermore, that higher impulsivity in BPD patients might be related to impaired prediction of aversive outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.