ReviewNeuroImage. Clinical2016
Pharmaco fMRI: Determining the functional anatomy of the effects of medication.
Review in NeuroImage. Clinical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Trial
- Dynamic Resting-State Network Biomarkers of Antidepressant Treatment Response.Biological psychiatry · 2022Trial
- Effect of mGluR2 positive allosteric modulation on frontostriatal working memory activation in schizophrenia.Molecular psychiatry · 2022Trial
- Anti-Seizure Medications Alter Functional and Effective Connectivity as Measured With Intracranial Electroencephalography.Brain and behavior · 2026Article
- Opioid-specific brain connectivity dynamics distinguish analgesia from secondary effects: Studies in male mice.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Altered Functional Connectivity and Amyloid Deposition in Posttraumatic Stress Disorder-Associated Cognitive Impairment.AJNR. American journal of neuroradiology · 2025Article
- Emotion anticipation and processing in depression: Behavioral, neural, and physiological reactivity.European psychiatry : the journal of the Association of European Psychiatrists · 2025Article
- Dynamic and Static Functional Gradient in Temporal Lobe Epilepsy With Hippocampal Sclerosis Versus Healthy Controls.CNS neuroscience & therapeutics · 2025Article
- Differential reorganization of episodic and semantic memory systems in epilepsy-related mesiotemporal pathology.Brain : a journal of neurology · 2024Article
- Classifying Unconscious, Psychedelic, and Neuropsychiatric Brain States with Functional Connectivity, Graph Theory, and Cortical Gradient Analysis.Brain sciences · 2024Article
- Elevating the field for applying neuroimaging to individual patients in psychiatry.Translational psychiatry · 2024Review
- Altered correlation of concurrently recorded EEG-fMRI connectomes in temporal lobe epilepsy.Network neuroscience (Cambridge, Mass.) · 2024Article
- Quantifying individual variability in neural control circuit regulation using single-subject fMRI.Computational brain & behavior · 2023Article
- In vivo mapping of pharmacologically induced functional reorganization onto the human brain's neurotransmitter landscape.Science advances · 2023Article
- The Role of fMRI in Drug Development: An Update.Advances in neurobiology · 2023Article
- The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives.Frontiers in network physiology · 2023Review
- Stress-related hippocampus activation mediates the association between polyvictimization and trait anxiety in adolescents.Social cognitive and affective neuroscience · 2022Article
- Pathophysiological Studies of Monoaminergic Neurotransmission Systems in Valproic Acid-Induced Model of Autism Spectrum Disorder.Biomedicines · 2022Review
- 7T ultra-high-field neuroimaging for mental health: an emerging tool for precision psychiatry?Translational psychiatry · 2022Review
- Altered trigeminothalamic spontaneous low-frequency oscillations in migraine without aura: a resting-state fMRI study.BMC neurology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Functional MRI studies have helped to elucidate underlying mechanisms in complex neurological and neuropsychiatric disorders. Disease processes often involve complex large-scale network interactions, extending beyond the presumed main disease focus. Given both the complexity of the clinical phenotype and the underlying dysfunctional brain circuits, so called pharmaco-fMRI (ph-MRI) studies probe pharmacological effects on functional neuro-anatomy, and can help to determine early treatment response, mechanisms of drug efficacy and side effects, and potentially advance CNS drug development. In this review, we discuss recent ph-MRI research in three major neuropsychiatric and neurological disorders and associated network alterations, namely selective serotonin and noradrenergic reuptake inhibitors in affective disorders and emotional processing circuits; antiepileptic drugs in epilepsy and cognitive networks; and stimulants in attention-deficit/hyperactivity disorder and networks of attention control. We conclude that ph-MRI studies show consistent and reproducible changes on disease relevant networks, and prove sensitive to early pharmacological effects on functional anatomy associated with disease. Further CNS drug research and development would benefit greatly from improved disease phenotyping, or biomarkers, using advanced imaging techniques.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.