ArticleCurrent behavioral neuroscience reports2016
Aerobic Exercise in People with Schizophrenia: Neural and Neurocognitive Benefits.
Article in Current behavioral neuroscience reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03270098 (Improving Cognition Via Exercise in Schizophrenia), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Cognition Via Exercise in Schizophrenia
Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- The pro-cognitive mechanisms of physical exercise in people with schizophrenia.British journal of pharmacology · 2017Pooled it
- Oxidative Stress and Inflammation in Early Onset First Episode Psychosis: A Systematic Review and Meta-Analysis.The international journal of neuropsychopharmacology · 2017Pooled it
- Aerobic Exercise Improves Cognitive Functioning in People With Schizophrenia: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2017Pooled it
- Telehealth-Based vs In-Person Aerobic Exercise in Individuals With Schizophrenia: Comparative Analysis of Feasibility, Safety, and Efficacy.JMIR mental health · 2025Trial
- Aerobic and Postural Strength Exercise Benefits in People with Schizophrenia.International journal of environmental research and public health · 2023Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Enhancement of aerobic fitness improves social functioning in individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Aerobic Exercise for Cognitive and Functional Enhancement in Schizophrenia: Evidence, Mechanisms, and Practical Recommendations.Schizophrenia bulletin open · 2026Article
- Cardiometabolic health and physical robustness map onto distinct patterns of brain structure and neurotransmitter systems.PLoS biology · 2025Article
- Thalamic nuclei volume partially mediates the effects of aerobic capacity on fatigue in people with multiple sclerosis.Journal of neurology · 2024Article
- Physical and Mental Health in Adolescence: Novel Insights from a transdiagnostic examination of FitBit data in the ABCD Study.Research square · 2023Article
- Evaluating a pilot community-based FITMIND exercise programme for psychosis in Hong Kong.BMC psychiatry · 2023Article
- The Impact of Sleep on Neurocognition and Functioning in Schizophrenia-Is It Time to Wake-Up?Journal of psychiatry and brain science · 2022Article
- Psychosis risk individuals show poor fitness and discrepancies with objective and subjective measures.Scientific reports · 2021Observational
- The Relationship between Overweight/Obesity and Executive Control in College Students: The Mediating Effect of BDNF and 5-HT.Life (Basel, Switzerland) · 2021Article
- The impact of inflammation on neurocognition and risk for psychosis: a critical review.European archives of psychiatry and clinical neuroscience · 2020Review
- The Effect of Aerobic Exercise on Physical and Cognitive Outcomes in a Small Cohort of Outpatients with Schizophrenia.Brain plasticity (Amsterdam, Netherlands) · 2020Article
- The synergistic benefits of physical and cognitive exercise in schizophrenia: Promoting motivation to enhance community effectiveness.Schizophrenia research. Cognition · 2020Article
- Considering the Microbiome in Stress-Related and Neurodevelopmental Trajectories to Schizophrenia.Frontiers in psychiatry · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Schizophrenia is characterized by extensive neurocognitive deficits, which are linked to greater disability, poorer functional outcome, and have been suggested to impact daily functioning more than clinical symptoms. Aerobic exercise (AE) has emerged as a potential intervention. This review examines the impact of AE on brain structure and function along with neurocognitive performance in individuals with schizophrenia. Preliminary evidence indicates that AE can increase hippocampal volume and cortical thickness, in addition to exerting a neuroprotective effect against hippocampal volume decrease and cortical thinning. There is also evidence that AE is able to significantly increase serum brain-derived neurotrophic factor (BDNF) levels, which are implicated in neurogenesis, neuroplasticity, and cognitive improvement. Finally, evidence suggests that AE plays a significant role in improving overall cognition, including improvements in processing speed, working memory, and visual learning. The authors discuss the implications of the findings and provide recommendations for future research and areas of inquiry.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.