Evidence map›Paper›PMID 27766121›Full record

ArticleJournal of hematopathology2016

Transformation of CLL to ALCL: the role of clonality studies in diagnostic molecular haematopathology.

Richard Colling, Daniel Royston, Elizabeth Soilleux

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hematopathology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard CollingDepartment of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK ; Department of Oncology, University of Oxford, Oxford, UK.
Daniel RoystonDepartment of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK ; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.
Elizabeth SoilleuxDepartment of Cellular Pathology, Oxford University Hospitals NHS Trust, Oxford, UK ; Nuffield Division of Clinical Laboratory Sciences, University of Oxford, Oxford, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clonality studies greatly assist in the diagnosis of challenging haematopathology cases. These robust and standardised tests aid the detection of clonal lymphoid populations and may assist in lymphocyte subtyping. In this case report, a gentleman presented with a high-grade transformation of a B cell neoplasm which histologically and immunophenotypically mimicked a T cell anaplastic large-cell lymphoma. With the aid of T cell and B cell receptor clonality studies, it was demonstrated that this tumour was in fact of B cell lineage. This report exemplifies the role of these increasingly used and relatively new molecular tests in unusual and difficult lymphoma presentations and highlights potential pitfalls in the interpretation of their results.

Indexed as

ClonalityLymphomaMolecular diagnosticsPCR

Identifiers

PMID27766121
PMCPMC5047934

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.