ArticleFrontiers in human neuroscience2016
Brain Changes in Responders vs. Non-Responders in Chronic Migraine: Markers of Disease Reversal.
Article in Frontiers in human neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06244823 (A Prospective Structural, Diffusion and Connectomics MRI Study on Migraine Patients Treated With Fremanezumab), which is not on this map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective Structural, Diffusion and Connectomics MRI Study on Migraine Patients Treated With Fremanezumab: The FreMRI Study
Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Botulinum toxin effects on biochemical biomarkers related to inflammation-associated head and neck chronic conditions: a systematic review of clinical research.Journal of neural transmission (Vienna, Austria : 1996) · 2025Pooled it
- Imaging the brain and vascular reactions to headache treatments: a systematic review.The journal of headache and pain · 2023Pooled it
- Headache-related circuits and high frequencies evaluated by EEG, MRI, PET as potential biomarkers to differentiate chronic and episodic migraine: Evidence from a systematic review.The journal of headache and pain · 2022Pooled it
- Treatment of chronic migraine with Botox (onabotulinumtoxinA): Development, insights, and impact.Medicine · 2023Trial
- The Use of Botulinum Toxin in the Management of Headache Disorders.Handbook of experimental pharmacology · 2021Trial
- Brain structural MRI changes before and after 6 months of preventive treatment with erenumab and onabotulinumtoxinA in migraine.The journal of headache and pain · 2026Article
- Article
- Insights from 25 years of onabotulinumtoxinA in migraine - mechanisms and management.Nature reviews. Neurology · 2024Review
- Searching for the Predictors of Response to BoNT-A in Migraine Using Machine Learning Approaches.Toxins · 2023Article
- Neurological soft signs are increased in migraine without aura: relationship with the affective status.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- The Use of Neuroimaging for Predicting Sumatriptan Treatment Response in Patients With Migraine.Frontiers in neurology · 2022Article
- The missing mechanistic link: Improving behavioral treatment efficacy for pediatric chronic pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Early alterations of cortical thickness and gyrification in migraine without aura: a retrospective MRI study in pediatric patients.The journal of headache and pain · 2021Article
- OnabotulinumtoxinA in Migraine: A Review of the Literature and Factors Associated with Efficacy.Journal of clinical medicine · 2021Review
- Structural MRI Analysis of Chronic Pain Patients Following Interdisciplinary Treatment Shows Changes in Brain Volume and Opiate-Dependent Reorganization of the Amygdala and Hippocampus.Pain medicine (Malden, Mass.) · 2020Article
- Structural neuroimaging findings in migraine patients with restless legs syndrome.Neuroradiology · 2020Article
- Brain Metabolism and Structure in Chronic Migraine.Current pain and headache reports · 2020Review
- Observational
- Shifting brain circuits in pain chronicity.Human brain mapping · 2019Article
- CALCA and TRPV1 genes polymorphisms are related to a good outcome in female chronic migraine patients treated with OnabotulinumtoxinA.The journal of headache and pain · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The aim of this study was to identify structural and functional brain changes that accompanied the transition from chronic (CM; ≥15 headache days/month) to episodic (EM; <15 headache days/month) migraine following prophylactic treatment with onabotulinumtoxinA (BoNT-A). Specifically, we examined whether CM patients responsive to prophylaxis (responders;
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.