Evidence map›Paper›PMID 27766064›Full record

ArticleThrombosis journal2016

Characteristics of Taiwanese patients of PNH in the international PNH registry.

Wen-Chien Chou, Wei-Han Huang, Ming-Chung Wang, Chao-Sung Chang, Shih-Peng Yeh, Tzeon-Jye Chiou, Yeu-Chin Chen, Tseng-Hsi Lin, Ming-Ching Shen, Taiwan PNH study group

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thrombosis journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01374360 (Paroxysmal Nocturnal Hemoglobinuria), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01374360 completednot on this map

Paroxysmal Nocturnal Hemoglobinuria (PNH) Registry

TypeobservationalSponsorAlexion Pharmaceuticals, Inc.Ran2004 to 2025Enrolled6,061ConditionsParoxysmal Nocturnal Hemoglobinuria
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wen-Chien ChouDepartment of Laboratory Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Wei-Han HuangDepartment of Hematology and Oncology, Hualien Tzu Chi Hospital, Hualien, Taiwan.
Ming-Chung WangDivision of Hematology and Oncology Department of Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
Chao-Sung ChangDepartment of Hematology and Oncology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Shih-Peng YehDepartment of Hematology and Oncology, China Medical University Hospital, Taichung, Taiwan.
Tzeon-Jye ChiouDepartment of Medicine and Division of Transfusion Medicine Taipei, Veterans General Hospital, Taipei, Taiwan.
Yeu-Chin ChenDivision of Hematology and Oncology, Department of Medicine, Tri-Service General Hospital, Taipei, Taiwan.
Tseng-Hsi LinDepartment of Hematology and Oncology, Taichung Veterans General Hospital, Taichung, Taiwan.
Ming-Ching ShenDepartment of Hematology and Oncology, Changhua Christian Hospital, Changhua, Taiwan.
Taiwan PNH study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParoxysmal nocturnal hemoglobinuria (PNH) is a rare and acquired hematopoietic stem cell disease, with florid clinical presentations. Although this disease has been characterized in the western countries, its clinical and laboratory features in Taiwan have not yet been reported.

resultsAs a part of an international prospective, non-interventional, observational registration trial of PNH, we have analyzed 63 patients recruited between 2009 and 2015 in Taiwan, with comparison to the 3857 patients in the rest of the world (ROW). The median age of diagnosis of our patients is 46 (range 9-84), without sex preponderance. While most of the clinical and laboratory presentations of our patients are similar to the ROW, ours have higher lactate dehydrogenase levels, lower hemoglobin, and higher frequencies of symptoms including shortness of breath and erectile dysfunction at the time of diagnosis. The incidence of thromboembolism was not statistically different between ours and the ROW (6.7 % vs 13.5 %,

conclusionsThis is the first systematic review on the Taiwanese PNH patients. Our analysis would provide key information about our PNH patients and would help understanding the basic characteristics of this rare disease in Taiwan.

trial registrationThis trial has been registered to ClinicalTrails.gov NCT01374360.

Indexed as

Paroxysmal nocturnal hemoglobinuriaTaiwan

Identifiers

PMID27766064
PMCPMC5056488

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