Evidence map›Paper›PMID 27766038›Full record

ArticleInternational journal of biological sciences2016

Indoxyl Sulfate Enhance the Hypermethylation of Klotho and Promote the Process of Vascular Calcification in Chronic Kidney Disease.

Jing Chen, Xiaoyan Zhang, Han Zhang, Tongqiang Liu, Hui Zhang, Jie Teng, Jun Ji, Xiaoqiang Ding

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 4 pooled it
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Osteoporosis in Patients with Chronic Kidney Diseases: A Systemic Review.International journal of molecular sciences · 2020
    Pooled it
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. [Potential of early diagnosis and targeted therapy for Klotho protein in chronic kidney disease].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jing ChenDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.; Kidney and Dialysis Institute of Shanghai, Shanghai, China.; Kidney and Blood Purification Laboratory of Shanghai, Shanghai, China.
Xiaoyan ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.; Kidney and Dialysis Institute of Shanghai, Shanghai, China.; Kidney and Blood Purification Laboratory of Shanghai, Shanghai, China.
Han ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Tongqiang LiuDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Hui ZhangDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Jie TengKidney and Dialysis Institute of Shanghai, Shanghai, China.
Jun JiKidney and Dialysis Institute of Shanghai, Shanghai, China.
Xiaoqiang DingDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.; Kidney and Dialysis Institute of Shanghai, Shanghai, China.; Kidney and Blood Purification Laboratory of Shanghai, Shanghai, China.
Fudan University · CNZhongshan Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic kidney disease (CKD) is a state of Klotho deficiency. The Klotho expression may be suppressed due to DNA hypermethylation in cancer cells so we have investigated the effects and possible mechanisms by which Klotho expression is regulated in human aortic smooth muscle cells (HASMCs). The vascular Klotho hypermethylation in radial arteries of patients with end-stage renal disease was described. Cultured HASMCs and 5/6-nephrectomized Sprague Dawley (SD) rats treated with indoxyl sulfate (IS) were used as

Indexed as

AnimalsCell LineDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesDNA MethylationGlucuronidaseHumansIndicanKidney Failure, ChronicKlotho ProteinsRatsRats, Sprague-DawleyRenal Insufficiency, ChronicTandem Mass SpectrometryVascular CalcificationDNA (Cytosine-5-)-Methyltransferase 1DNA (Cytosine-5-)-MethyltransferasesGlucuronidaseIndicanKlotho ProteinsChronic kidney disease.DNA methylationDNA methyltransferaseIndoxyl sulfateKlothoVascular calcification

Identifiers

PMID27766038
PMCPMC5069445
OpenAlexW2540545334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.