Evidence map›Paper›PMID 27766031›Full record

ArticleInternational journal of biological sciences2016

Class A Scavenger Receptor Exacerbates Osteoclastogenesis by an Interleukin-6-Mediated Mechanism through ERK and JNK Signaling Pathways.

Shuyu Guo, Yuanyuan Ni, Jingjing Ben, Yang Xia, Tingting Zhou, Dongyue Wang, Jieli Ni, Hui Bai, Lin Wang, Junqing Ma and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of biological sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Scavenger receptor A1 participates in uptake ofEmerging microbes & infections · 2021
    Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. GATA Binding Protein 4 Regulates Tooth Root Dentin DevelopmentInternational journal of biological sciences · 2020
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. American journal of translational research · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Shuyu GuoJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Yuanyuan NiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Jingjing BenAtherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, China.
Yang XiaJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Tingting ZhouJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Dongyue WangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Jieli NiJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Hui BaiAtherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, China.
Lin WangJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Junqing MaJiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, China.
Qi ChenAtherosclerosis Research Center, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoclasts originate from bone marrow monocyte/macrophage lineage cells, which are important for bone health. Class A scavenger receptor (SR-A) is a multifunctional molecule that functions during differentiation of monocyte into macrophages and osteoclasts. To further characterize the role of SR-A in osteoclasts, we used the murine tooth movement model (TM) and the murine anterior cruciate ligament transection model of osteoarthritis (ACLT OA). In these two models the bones involved are of different origin and have different properties. Bone resorption was decreased in SR-A

Indexed as

AnimalsEnzyme-Linked Immunosorbent AssayExtracellular Signal-Regulated MAP KinasesInterleukin-6JNK Mitogen-Activated Protein KinasesMacrophagesMiceOsteoarthritisOsteoclastsOsteogenesisRANK LigandScavenger Receptors, Class ASignal TransductionX-Ray MicrotomographyExtracellular Signal-Regulated MAP KinasesInterleukin-6JNK Mitogen-Activated Protein KinasesRANK LigandScavenger Receptors, Class AERKIL-6JNK.OsteoclastsSR-A

Identifiers

PMID27766031
PMCPMC5069438
OpenAlexW2519134379

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.