Evidence map›Paper›PMID 27765935›Full record

ArticleOncotarget2016

Gene polymorphisms are associated with clinical outcome in Chinese resected laryngeal carcinoma patients.

Peng Chen, Zhengshuai Chen, Jinglie Li, Hua Yang, Yuanyuan Zhu, Ning Zhang, Mengdan Yan, Yuan Shao, Chao Chen, Tianbo Jin

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Peng ChenThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Zhengshuai ChenThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Jinglie LiThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Hua YangThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Yuanyuan ZhuKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
Ning ZhangKey Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an, Shaanxi 710069, China.
Mengdan YanThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Yuan ShaoDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Xi'an, Jiaotong University, Xi'an, Shaanxi 710061, China.
Chao ChenThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Tianbo JinThe National Engineering Research Centre for Miniaturized Detection Systems, College of Life Science, Northwest University, Xi'an, Shaanxi 710069, China.
Northwest University · CNMinistry of Education of the People's Republic of China · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We examined the multigenetic index on the progression of laryngeal carcinoma in Chinese population. This study aims to assess the effects of single nucleotide polymorphisms (SNPs) on survival of Laryngeal Carcinoma (LC) patients. Eighteen SNPs were selected and genotyped using the Sequenom iPLEX genotyping system in a cohort of 170 resected Chinese LC patients. Multivariate Cox proportional hazards model and Kaplan-Meier curve were used for the prognosis analysis. Overall, the median survival time (MST) was 38.00 months. The one, three and five year Kaplan-Meier survival rate was 0.847 ± 0.028, 0.572 ± 0.038 and 0.471 ± 0.041 respectively. The risks of death with the Hazard Ratio (HR) [95% confidence intervals] (CI) of 2.40 (1.15-4.50), 2.17 (1.45-3.25), 2.39 (1.58-3.62), 3.29 (2.10-5.18), respectively. There was significant associations between the SNPs and OS when the entire study population was examined. The rs1321311 TG genotype (vs.GG), rs2494938 AA genotype (vs. GG) and rs9363918 TG genotype (vs. GG) were associated with a worse prognosis for OS (adjusted HR = 1.64; 95%confidence interval = 1.07-2.51; P = 0.022, adjusted HR = 2.85; P =0.12; adjusted HR = 1.78; P = 0.009; respectively).The results suggest for the first time that these gene polymorphisms may serve as an independent prognostic marker for LC patients.

Indexed as

Polymorphism, Single NucleotideAdultAgedAged, 80 and overCyclin-Dependent Kinase Inhibitor p21GenotypeHumansLaryngeal NeoplasmsMiddle AgedPrognosisProportional Hazards ModelsUbiquitin-Protein LigasesCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21parkin proteinUbiquitin-Protein Ligaseslaryngeal carcinomaoverall survivalprognosisprognostic markersingle-nucleotide polymorphism

Identifiers

PMID27765935
PMCPMC5342113
OpenAlexW2525683462

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.