Evidence map›Paper›PMID 27765795›Full record

ReviewPathogens and disease2016

Disseminated infections with antibiotic-resistant non-typhoidal Salmonella strains: contributions of host and pathogen factors.

Kristen L Lokken, Gregory T Walker, Renée M Tsolis

Open access · bronzeAbstract readReview
In one paragraph

Review in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
7.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Whole-genome sequencing data ofData in brief · 2025
    Article
  5. African health sciences · 2025
    Article
  6. Article
  7. Article
  8. Comparative Genomic and Phylogenetic Analysis ofTransboundary and emerging diseases · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Meningitis and Bacteremia by Unusual Serotype ofInterdisciplinary perspectives on infectious diseases · 2024
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Prevalence, Serotype Distribution and Antimicrobial Resistance of Non-TyphoidalFrontiers in cellular and infection microbiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Kristen L LokkenMedical Microbiology and Immunology, University of California, One Shields Avenue, Davis, CA 95616, USA.
Gregory T WalkerMedical Microbiology and Immunology, University of California, One Shields Avenue, Davis, CA 95616, USA.
Renée M TsolisMedical Microbiology and Immunology, University of California, One Shields Avenue, Davis, CA 95616, USA rmtsolis@ucdavis.edu.
University of California Davis Medical Center · USUniversity of California, Davis · US

Funding

Animal Models of Infectious Diseases Training ProgramT32AI060555 · NIAID · UNIVERSITY OF CALIFORNIA DAVIS · PI MCSORLEY, STEPHEN J · 2004 to 2025
$3.3M
Pathogenesis of Salmonella bacteremiaR01AI098078 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TSOLIS, RENEE M · 2012 to 2016
$1.8M
Pathogenesis of Salmonella BacteremiaR56AI098078 · NIAID · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TSOLIS, RENEE M · 2018 to 2018
$384k
NIAID NIH HHS R01 AI098078NIAID NIH HHS R56 AI098078
6 · The paper itself

Abstract

Non-typhoidal Salmonella enterica serovars (NTS) are generally associated with gastroenteritis; however, the very young and elderly, as well as individuals with compromised immunity, are at risk of developing disseminated infection that can manifest as bacteremia or focal infections at systemic sites. Disseminated NTS infections can be fatal and are responsible for over 600 000 deaths annually. Most of these deaths are in sub-Saharan Africa, where multidrug-resistant NTS clones are currently circulating in a population with a high proportion of individuals that are susceptible to disseminated disease. This review considers how genome degradation observed in African NTS isolates has resulted in phenotypic differences in traits related to environmental persistence and host-pathogen interactions. Further, it discusses host mechanisms promoting susceptibility to invasive infection with NTS in individuals with immunocompromising conditions. We conclude that mechanistic knowledge of how risk factors compromise immunity to disseminated NTS infection will be important for the design of interventions to protect against systemic disease.

Indexed as

BacteremiaDrug Resistance, BacterialHost-Pathogen InteractionsAfricaAnti-Bacterial AgentsDisease SusceptibilityHumansMicrobial Sensitivity TestsPhenotypeRisk FactorsSalmonellaSalmonella InfectionsAnti-Bacterial Agentsbacteremiaco-infectionmalariaSalmonella

Identifiers

PMID27765795
PMCPMC5985489
OpenAlexW2529828853

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.