ArticleArteriosclerosis, thrombosis, and vascular biology2016
Microvascular Endothelial Dysfunction in Sedentary, Obese Humans Is Mediated by NADPH Oxidase: Influence of Exercise Training.
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Article in Arteriosclerosis, thrombosis, and vascular biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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39citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
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Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Exercise during hemodialysis does not affect the phenotype or prothrombotic nature of microparticles but alters their proinflammatory function.Physiological reports · 2018Trial
- Exercise and Endothelial Function: Insights from a Redox Perspective.Current atherosclerosis reports · 2026Review
- Local apocynin improves acetylcholine- but not insulin-mediated vasodilation in the cutaneous microvasculature of women with a history of gestational diabetes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Redox Regulation of Microvascular Physiology and Pathophysiology: Insights into Therapeutic Strategies and Limitations.Antioxidants & redox signaling · 2025Review
- Oxidative Stress in the Pathophysiology of Chronic Venous Disease: An Overview.Antioxidants (Basel, Switzerland) · 2025Review
- Unraveling Skeletal Muscle Insulin Resistance: Molecular Mechanisms and the Restorative Role of Exercise.Circulation research · 2025Review
- Creatine monohydrate supplementation and NOX impact skeletal muscle microvascular blood flow: a pilot study.Pflugers Archiv : European journal of physiology · 2025Article
- Dietary intake of live microbes mitigates the mortality risk associated with sedentary behavior in US hypertensive individuals.Scientific reports · 2025Article
- Multiplex proteomics identifies inflammation-related plasma biomarkers for aging and cardio-metabolic disorders.Clinical proteomics · 2024Article
- Cyclooxygenase inhibition does not blunt thermal hyperemia in skeletal muscle of humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Non-neuronal cell-derived acetylcholine, a key modulator of the vascular endothelial function in health and disease.Frontiers in cardiovascular medicine · 2024Review
- Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets.Cellular & molecular biology letters · 2023Article
- Endothelium-Derived Relaxing Factors and Endothelial Function: A Systematic Review.Biomedicines · 2022Review
- Inhibiting NADPH Oxidases to Target Vascular and Other Pathologies: An Update on Recent Experimental and Clinical Studies.Biomolecules · 2022Review
- Physical Exercise Protects Against Endothelial Dysfunction in Cardiovascular and Metabolic Diseases.Journal of cardiovascular translational research · 2022Review
- Review
- Oxidative Stress, Vascular Endothelium, and the Pathology of Neurodegeneration in Retina.Antioxidants (Basel, Switzerland) · 2022Review
- Hypertension and COVID-19: Current Evidence and Perspectives.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2022Review
- Acute heat exposure improves microvascular function in skeletal muscle of aged adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Characterizing the interindividual postexercise hypotension response for two order groups of concurrent training in patients with morbid obesity.Frontiers in physiology · 2022Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Justin D La FavorFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.). jlafavo3@jhmi.edu.
Gabriel S DubisFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
Huimin YanFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
Joseph D WhiteFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
Margaret A M NelsonFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
Ethan J AndersonFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
Robert C HicknerFrom the Human Performance Laboratory, Departments of Kinesiology (J.D.L.F., G.S.D., H.Y., J.D.W., R.C.H.), Pharmacology and Toxicology (M.A.M.N., E.J.A.), Physiology (R.C.H.), East Carolina Diabetes and Obesity Institute (J.D.L.F., M.A.M.N., E.J.A., R.C.H.), Center for Health Disparities (R.C.H.), East Carolina University, Greenville, NC; Department of Urology, The James Buchannan Brady Urological Institute, The Johns Hopkins School of Medicine, Baltimore, MD (J.D.L.F.); Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City (E.J.A.); and Department of Biokinetics, Exercise and Leisure Science, University of KwaZulu-Natal, Durban, South Africa (R.C.H.).
University of Iowa · USJohns Hopkins University · US
Funding
Myocardial redox status, catecholamine metabolism and post-operative arrhythmiaR01HL122863 · NHLBI · UNIVERSITY OF IOWA · PI ANDERSON, ETHAN JOHN · 2014 to 2018
$2.1MNADPH Oxidase and Microvascular Dysfunction in ObesityR15HL113854 · NHLBI · FLORIDA STATE UNIVERSITY · PI HICKNER, ROBERT C · 2013 to 2018
$884kRegulation of eNOS by S-Nitrosylation in Diet Associated Erectile DysfunctionF32DK100082 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LAFAVOR, JUSTIN DAVID · 2014 to 2016
$149kNHLBI NIH HHS R01 HL122863NHLBI NIH HHS R15 HL113854NIDDK NIH HHS F32 DK100082
Abstract
objectiveThe objectives of this study were to determine the impact of in vivo reactive oxygen species (ROS) on microvascular endothelial function in obese human subjects and the efficacy of an aerobic exercise intervention on alleviating obesity-associated dysfunctionality. APPROACH AND
resultsYoung, sedentary men and women were divided into lean (body mass index 18-25; n=14), intermediate (body mass index 28-32.5; n=13), and obese (body mass index 33-40; n=15) groups. A novel microdialysis technique was utilized to detect elevated interstitial hydrogen peroxide (H
conclusionsThis study implicates NADPH oxidase as a source of excessive ROS production in skeletal muscle of obese individuals and links excessive NADPH oxidase-derived ROS to microvascular endothelial dysfunction in obesity. Furthermore, aerobic exercise training proved to be an effective strategy for alleviating these maladies.
Indexed as
ExerciseOxidative StressSedentary BehaviorVasodilationAdolescentAdultBody Mass IndexEndothelium, VascularEnzyme InhibitorsFemaleHumansHydrogen PeroxideMaleMicrodialysisMicrovesselsNADPH OxidasesCYBA protein, humanEnzyme InhibitorsHydrogen PeroxideNADPH OxidasesNCF2 protein, humanneutrophil cytosol factor 67Kneutrophil cytosolic factor 1PhosphoproteinsSuperoxidesVasodilator Agentsacetylcholinehydrogen peroxidemicrodialysisobesitysuperoxide
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