Evidence map›Paper›PMID 27765747›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2016

Hydrogen sulfide-induced vasodilation mediated by endothelial TRPV4 channels.

Jay S Naik, Jessica M Osmond, Benjimen R Walker, Nancy L Kanagy

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 84 citations in OpenAlex.

  1. Article
  2. Review
  3. Guidelines for evaluating endothelial function in vascular tissue.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. HBiomolecules · 2024
    Article
  13. Review
  14. Review
  15. Review
  16. Impact of aging on vascular ion channels: perspectives and knowledge gaps across major organ systems.American journal of physiology. Heart and circulatory physiology · 2023
    Review
  17. Review
  18. Clinical Potential of Hydrogen Sulfide in Peripheral Arterial Disease.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jay S NaikDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico jnaik@salud.unm.edu.ORCID 0000-0002-5725-4664
Jessica M OsmondDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Benjimen R WalkerDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
Nancy L KanagyDepartment of Cell Biology and Physiology, University of New Mexico, Albuquerque, New Mexico.
University of New Mexico · US

Funding

MINORITY INSTITUTIONAL RESEARCH TRAINING PROGRAM (T32)T32HL007736 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI RESTA, THOMAS C · 1993 to 2025
$6.5M
Hydrogen sulfide regulation of vascular tone and blood pressureR01HL123301 · NHLBI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI KANAGY, NANCY L · 2015 to 2018
$1.5M
Endothelin vasoconstriction in a rat model of sleep apnea-induced hypertension.R01HL082799 · NHLBI · UNIVERSITY OF NEW MEXICO · PI KANAGY, NANCY L · 2007 to 2010
$1.5M
NHLBI NIH HHS R01 HL082799NHLBI NIH HHS R01 HL123301NHLBI NIH HHS T32 HL007736
6 · The paper itself

Abstract

Hydrogen sulfide (H

Indexed as

AnimalsEndothelial CellsEndothelium, VascularGasotransmittersHydrogen SulfideLarge-Conductance Calcium-Activated Potassium ChannelsLeucineMaleMesenteric ArteriesRatsRats, Sprague-DawleySulfonamidesTRPV Cation ChannelsVasodilationGasotransmittersHydrogen SulfideLarge-Conductance Calcium-Activated Potassium ChannelsLeucineN-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamideSulfonamidesTrpv4 protein, ratTRPV Cation ChannelsBK channelendotheliumhydrogen sulfideTRPV4vasodilation

Identifiers

PMID27765747
PMCPMC5206343
OpenAlexW2527941006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.