ArticleAmerican journal of physiology. Heart and circulatory physiology2016
Heart-lung interaction in a model of COPD: importance of lung volume and direct ventricular interaction.
Article in American journal of physiology. Heart and circulatory physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Heart Failure with Preserved Ejection Fraction and Diastolic Dysfunction in Patients with Chronic Obstructive Pulmonary Disease: a Systematic Review.Current heart failure reports · 2026Pooled it
- Heart-Lung Interactions in HFpEF: Dynamic Hyperinflation and Exercise PCWP.JACC. Heart failure · 2025Trial
- Induction of dynamic hyperinflation by expiratory resistance breathing in healthy subjects - an efficacy and safety study.Experimental physiology · 2021Trial
- Relationship between quantitative CT and cardiac function in patients with severe COPD exacerbations (ECOPD).BMJ open respiratory research · 2026Article
- Challenges in the Early Diagnosis, Screening and Management of Heart Failure in Patients with Chronic Obstructive Pulmonary Disease.Journal of clinical medicine · 2026Review
- Females exhibit greater cardiac volume reductions with expiratory muscle loading during submaximal exercise compared to males.The Journal of physiology · 2026Article
- Biological pathways and mechanisms linking COPD and cardiovascular disease.Therapeutic advances in chronic disease · 2025Review
- Cardio-respiratory interactions in acute asthma.Frontiers in physiology · 2023Review
- A new approach to improve the hemodynamic assessment of cardiac function independent of respiratory influence.Scientific reports · 2021Article
- Cardiorespiratory coupling is associated with exercise capacity in patients with chronic obstructive pulmonary disease.BMC pulmonary medicine · 2021Observational
- Effects of Dynamic Hyperinflation on Left Ventricular Diastolic Function in Healthy Subjects - A Randomized Controlled Crossover Trial.Frontiers in medicine · 2021Article
- How to ventilate obstructive and asthmatic patients.Intensive care medicine · 2020Review
- Impaired central hemodynamics in chronic obstructive pulmonary disease during submaximal exercise.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- Acute volume loading exacerbates direct ventricular interaction in a model of COPD.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Article
- A History of Asthma From Childhood and Left Ventricular Mass in Asymptomatic Young Adults: The Bogalusa Heart Study.JACC. Heart failure · 2017Article
- Positive end-expiratory pressure attenuates hemodynamic effects induced by an overload of inspiratory muscles in patients with COPD.International journal of chronic obstructive pulmonary disease · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic obstructive pulmonary disease (COPD) is associated with dynamic lung hyperinflation (DH), increased pulmonary vascular resistance (PVR), and large increases in negative intrathoracic pressure (nITP). The individual and interactive effect of these stressors on left ventricular (LV) filling, emptying, and geometry and the role of direct ventricular interaction (DVI) in mediating these interactions have not been fully elucidated. Twenty healthy subjects were exposed to the following stressors alone and in combination: 1) inspiratory resistive loading of -20 cmH
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.