ArticleAJNR. American journal of neuroradiology2017
Endovascular Therapy of M2 Occlusion in IMS III: Role of M2 Segment Definition and Location on Clinical and Revascularization Outcomes.
Article in AJNR. American journal of neuroradiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Angiographic Systems for Classifying Distal Arterial Occlusions.Cerebrovascular diseases (Basel, Switzerland) · 2023Pooled it
- Endovascular Treatment: The Role of Dominant Caliber M2 Segment Occlusion in Ischemic Stroke.Stroke · 2019Trial
- Thrombectomy for medium-sized cerebral vessel occlusion: Size does matter.European stroke journal · 2026Observational
- Frontline aspiration versus stent retriever thrombectomy for M2 occlusions: Insights from the STAR registry.European stroke journal · 2026Article
- Thrombectomy for medium-sized cerebral vessel occlusion: Size does matter.European stroke journal · 2025Article
- Cross-Sectional Imaging Modalities in Correlation to the Thrombolysis in Cerebral Infarction Score: The Next Frontier in Adjunctive Endovascular Stroke Therapy.Stroke (Hoboken, N.J.) · 2025Review
- Anatomical distribution and clinical significance of middle cerebral artery M2 segment vessel occlusions and its cortical branches in acute ischaemic stroke patients.BMJ neurology open · 2023Article
- Aspiration thrombectomy of M2 middle cerebral artery occlusion to treat acute ischemic stroke: A core lab-adjudicated subset analysis from the COMPLETE registry and literature review.Frontiers in neurology · 2023Article
- Mechanical thrombectomy in stroke patients with acute occlusion of the M1- compared to the M2-segment: Safety, efficacy, and clinical outcome.The neuroradiology journal · 2022Article
- Endovascular treatment for acute M2 occlusion stroke within 6 hours-a retrospective real-world evidence.Frontiers in cardiovascular medicine · 2022Article
- Diagnostic accuracy of automated occlusion detection in CT angiography using e-CTA.International journal of stroke : official journal of the International Stroke Society · 2022Article
- Multiphase CT Angiography: A Useful Technique in Acute Stroke Imaging-Collaterals and Beyond.AJNR. American journal of neuroradiology · 2021Review
- Mechanical thrombectomy in acute middle cerebral artery M2 segment occlusion with regard to vessel involvement.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Aspiration thrombectomy as the first-line treatment of M2 occlusions.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020Article
- ADAPT technique in ischemic stroke treatment of M2 middle cerebral artery occlusions in comparison to M1 occlusions: Post hoc analysis of the PROMISE study.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020Article
- Meta-Analysis of Endovascular Treatment for Acute M2 Occlusion.Journal of Korean Neurosurgical Society · 2019Article
- Contact Aspiration versus Stent-Retriever Thrombectomy for Distal Middle Cerebral Artery Occlusions in Acute Ischemic Stroke: Meta-Analysis.Neurointervention · 2018Article
- Frontline ADAPT therapy to treat patients with symptomatic M2 and M3 occlusions in acute ischemic stroke: initial experience with the Penumbra ACE and 3MAX reperfusion system.Journal of neurointerventional surgery · 2018Article
- Comparison of Endovascular Treatment with Intravenous Thrombolysis for Isolated M2 Segment of Middle Cerebral Artery Occlusion in Acute Ischemic Stroke.Journal of vascular and interventional neurology · 2017Article
- Caution; Confusion Ahead….AJNR. American journal of neuroradiology · 2017Article
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
Abstract
background and purposeUncertainty persists regarding the safety and efficacy of endovascular therapy of M2 occlusions following IV tPA. We reviewed the impact of revascularization on clinical outcomes in 83 patients with M2 occlusions in the Interventional Management of Stroke III trial according to specific M1-M2 segment anatomic features. MATERIALS AND
methodsPerfusion of any M2 branch distinguished M2-versus-M1 occlusion. Prespecified modified TICI and arterial occlusive lesion revascularization and clinical mRS 0-2 end points at 90 days for endovascular therapy-treated M2 occlusions were analyzed. Post hoc analyses of the relationship of outcomes to multiple baseline angiographic M2 and M1 subgroup characteristics were performed.
resultsOf 83 participants with M2 occlusion who underwent endovascular therapy, 41.0% achieved mRS 0-2 at 90 days, including 46.6% with modified TICI 2-3 reperfusion compared with 26.1% with modified TICI 0-1 reperfusion (risk difference, 20.6%; 95% CI, -1.4%-42.5%). mRS 0-2 outcome was associated with reperfusion for M2 trunk (n = 9) or M2 division (n = 42) occlusions, but not for M2 branch occlusions (n = 28). Of participants with trunk and division occlusions, 63.2% with modified TICI 2a and 42.9% with modified TICI 2b reperfusion achieved mRS 0-2 outcomes; mRS 0-2 outcomes for M2 trunk occlusions (33%) did not differ from distal (38.2%) and proximal (26.9%) M1 occlusions.
conclusionsmRS 0-2 at 90 days was dependent on reperfusion for M2 trunk but not for M2 branch occlusions. For M2 division occlusions, good outcome with modified TICI 2b reperfusion did not differ from that in modified TICI 2a. M2 segment definition and occlusion location may contribute to differences in revascularization and good outcome between Interventional Management of Stroke III and other endovascular therapy studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.