Evidence map›Paper›PMID 27764938›Full record

ArticleACS infectious diseases2017

1,2,4-Triazolidine-3-thiones Have Specific Activity against Acinetobacter baumannii among Common Nosocomial Pathogens.

Brendan W Corey, Mitchell G Thompson, Lauren E Hittle, Anna C Jacobs, Edward A Asafo-Adjei, William M Huggins, Roberta J Melander, Christian Melander, Robert K Ernst, Daniel V Zurawski

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Brendan W CoreyWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland 20910, United States.
Mitchell G ThompsonWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland 20910, United States.
Lauren E HittleDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry , Baltimore, Maryland 21201, United States.
Anna C JacobsWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland 20910, United States.
Edward A Asafo-AdjeiDepartment of Veterinary Medicine, Walter Reed Army Institute of Research , Silver Spring, Maryland 20910, United States.
William M HugginsDepartment of Chemistry, North Carolina State University , Raleigh, North Carolina 27695-8024, United States.
Roberta J MelanderDepartment of Chemistry, North Carolina State University , Raleigh, North Carolina 27695-8024, United States.
Christian MelanderDepartment of Chemistry, North Carolina State University , Raleigh, North Carolina 27695-8024, United States.
Robert K ErnstDepartment of Microbial Pathogenesis, University of Maryland School of Dentistry , Baltimore, Maryland 21201, United States.
Daniel V ZurawskiWound Infections Department, Bacterial Diseases Branch, Walter Reed Army Institute of Research , Silver Spring, Maryland 20910, United States.
Walter Reed Army Institute of Research · USNorth Carolina State University · USUniversity of Maryland, Baltimore · US

Funding

NMR STUDIES OF BACTERIAL REGULATORY PROTEINSR01GM055769 · NIGMS · WADSWORTH CENTER · PI CAVANAGH, JOHN, MELANDER, CHRISTIAN COREY · 1998 to 2017
$3.8M
NIGMS NIH HHS R01 GM055769
6 · The paper itself

Abstract

Acinetobacter baumannii are Gram-negative bacilli that pose a constant threat to susceptible patients because of increased resistance to multiple antibiotics and persistence in the hospital environment. After genome analysis, we discovered that A. baumannii harbors genes that share homology to an enzymatic pathway that elongates long-chain fatty acids (LCFA) in fungi. Previously, 1,2,4-triazolidine-3-thiones (T-3-Ts) were shown to inhibit hyphae production in fungi, and this same LCFA elongation pathway was implicated as the possible target. Therefore, we investigated if T-3-Ts also have activity against multidrug-resistant A. baumannii. Surprisingly, all of the clinical isolates of A. baumannii that were tested have susceptibility to ECC145 and ECC188 with MIC

Indexed as

Acinetobacter baumanniiAnti-Bacterial AgentsDrug DiscoveryDrug Resistance, Multiple, BacterialHumansMicrobial Sensitivity TestsThiazolesTriazolesAnti-Bacterial AgentsECC 145ECC 188ThiazolesTriazolesantibacterialantibioticESKAPE pathogensfatty acidsfungiGram-negative membrane

Identifiers

PMID27764938
PMCPMC5798234
OpenAlexW2533669131

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.