ReviewJournal of orthopaedic research : official publication of the Orthopaedic Research Society2017
Post-traumatic osteoarthritis of the ankle: A distinct clinical entity requiring new research approaches.
Review in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05465382 (The Effect of Early Saline Lavage on Synovial Fluid Composition Following Human Intra-Articular Ankle Fracture), which is not on this map. Cited by 73 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Early Saline Lavage on Synovial Fluid Composition Following Human Intra-Articular Ankle Fracture
Who cites it
73 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Direction-specific effects of balance training on dynamic balance in athletes with chronic ankle instability: a multilevel meta-analysis of randomized controlled trials.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Limited evidence in support of bone marrow aspirate concentrate as an additive to the bone marrow stimulation for osteochondral lesions of the talus: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Total ankle replacement versus ankle arthrodesis for patients aged 50-85 years with end-stage ankle osteoarthritis: the TARVA RCT.Health technology assessment (Winchester, England) · 2023Pooled it
- [Arthroscopy in the treatment of acute and chronic syndesmotic injuries of the ankle joint].Operative Orthopadie und Traumatologie · 2025Trial
- [Long-term outcomes after ankle fracture-Where do we stand?]Unfallchirurgie (Heidelberg, Germany) · 2026Review
- Article
- Three-Dimensional Osseous Alignment and Morphology Patterns of Ankle and Hindfoot Osteoarthritis.Foot & ankle international · 2026Article
- Donor Site Morbidity After Talar Mosaicplasty: Arthroscopic Medial Femoral Condyle vs Mini-Open Lateral Femoral Condyle Harvesting.Foot & ankle orthopaedics · 2026Article
- Open vs Arthroscopic Tibiotalar Arthrodesis: A Comparative Cohort Study from an Asian Tertiary Center.Foot & ankle orthopaedics · 2026Article
- Longitudinal 3D Shape and Alignment Analysis of Post-traumatic Osteoarthritis After Tibial Plafond Fractures.Foot & ankle orthopaedics · 2026Article
- Development and incremental value assessment of a risk prediction model for post-traumatic osteoarthritis following ankle fracture surgery: a prospective study.BMC musculoskeletal disorders · 2026Article
- Functional and Radiological Benefits of Adding Fibular Osteotomy to Supramalleolar Osteotomy in Ankle Osteoarthritis.Medical science monitor : international medical journal of experimental and clinical research · 2026Article
- Modeling and simulation of a porous mobility total ankle arthroplasty implant: enhancing bone-in growth and reducing micromotion for improved fixation.Journal of orthopaedic surgery and research · 2026Article
- Rate of Developing Charcot Arthropathy Following Ankle Injuries in Patients with Diabetes: A Two-Year Follow-up.Orthopedic reviews · 2026Article
- Chronic anterior talofibular ligament rupture is associated with bilateral knee alterations and reduced ankle plantar flexor moment during gait.Frontiers in sports and active living · 2026Article
- Achilles Allograft Reconstruction for Ankle Multiligament Injuries in a Patient Presenting With Rotational Ankle Instability: A Surgical Technique.Case reports in surgery · 2026Article
- Temporary Transarticular Screw Fixation for Traumatic Peritalar Instability After Talar Fracture-Dislocation.Foot & ankle orthopaedics · 2026Article
- Bone Marrow Aspirate Concentrate to Treat Ankle Osteoarthritis: A Narrative Review of Progress and Challenges.Cartilage · 2025Article
- Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- Synovial Dysregulation in Ankle Osteoarthritis: Molecular Insights and Pathogenetic Pathways.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The diagnosis of ankle osteoarthritis (OA) is increasing as a result of advancements in non-invasive imaging modalities such as magnetic resonance imaging, improved arthroscopic surgical technology and heightened awareness among clinicians. Unlike OA of the knee, primary or age-related ankle OA is rare, with the majority of ankle OA classified as post-traumatic (PTOA). Ankle trauma, more specifically ankle sprain, is the single most common athletic injury, and no effective therapies are available to prevent or slow progression of PTOA. Despite the high incidence of ankle trauma and OA, ankle-related OA research is sparse, with the majority of clinical and basic studies pertaining to the knee joint. Fundamental differences exist between joints including their structure and molecular composition, response to trauma, susceptibility to OA, clinical manifestations of disease, and response to treatment. Considerable evidence suggests that research findings from knee should not be extrapolated to the ankle, however few ankle-specific preclinical models of PTOA are currently available. The objective of this article is to review the current state of ankle OA investigation, highlighting important differences between the ankle and knee that may limit the extent to which research findings from knee models are applicable to the ankle joint. Considerations for the development of new ankle-specific, clinically relevant animal models are discussed. © 2016 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 35:440-453, 2017.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.