ArticleBritish journal of cancer2016
Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.
Article in British journal of cancer, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 3 of them syntheses that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 3 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Dietary patterns and colorectal cancer risk: Global Cancer Update Programme (CUP Global) systematic literature review.The American journal of clinical nutrition · 2025Pooled it
- Pooled it
- Dairy products and colorectal cancer in middle eastern and north African countries: a systematic review.BMC cancer · 2018Pooled it
- Lifestyle Changes and Colorectal Neoplasia Risk During Colonoscopy Surveillance: A Stage 1 Registered Report.Cancer medicine · 2026Article
- Evolution of enteric viruses in the progression of colorectal cancer via the adenoma-carcinoma sequence pathway.Virus research · 2025Article
- The role of gut microbiota in the formation of IBD, a typical chronic intestinal inflammatory disease.Frontiers in microbiology · 2025Review
- Association of dietary intake with cancer of the digestive system: a cross-sectional study.Frontiers in nutrition · 2025Article
- Article
- Autoimmune and Metabolic Diseases and the Risk of Early-Onset Colorectal Cancer, a Nationwide Nested Case-Control Study.Cancers · 2023Article
- Nutrient Patterns and Its Association and Metabolic Syndrome among Chinese Children and Adolescents Aged 7-17.Nutrients · 2022Article
- The role of gut microbiota in the development of colorectal cancer: a review.International journal of colorectal disease · 2022Review
- Dietary Fat Intake andNutrients · 2022Article
- Association of dietary and nutrient patterns with systemic inflammation in community dwelling adults.Frontiers in nutrition · 2022Article
- Colorectal Cancer Progression Is Potently Reduced by a Glucose-Free, High-Protein Diet: Comparison to Anti-EGFR Therapy.Cancers · 2021Article
- Exploring the Role of Gut Microbiome in Colon Cancer.Applied biochemistry and biotechnology · 2021Review
- Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation.Biomedicines · 2021Article
- Nutrient patterns and depressive symptoms among Australian adults.European journal of nutrition · 2021Article
- Diet, Microbiota, and Colorectal Cancer.iScience · 2019Review
- Microbiome and colorectal cancer: Roles in carcinogenesis and clinical potential.Molecular aspects of medicine · 2019Review
- Common dietary patterns and risk of cancers of the colon and rectum: Analysis from the United Kingdom Women's Cohort Study (UKWCS).International journal of cancer · 2018Article
Corrections and comments
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Authors and funding
49 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundMuch of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.
methodsAmong 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.
resultsDuring an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.
conclusionsAnalysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.