Evidence map›Paper›PMID 27764772›Full record

SynthesisOncotarget2016

Gene-environment interaction for polymorphisms in ataxia telangiectasia-mutated gene and radiation exposure in carcinogenesis: results from two literature-based meta-analyses of 27120 participants.

Yuguang Zhao, Lei Yang, Di Wu, Hua He, Mengmeng Wang, Tingwen Ge, Yudi Liu, Huimin Tian, Jiuwei Cui, Lin Jia and 2 more

Open access · diamondAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Yuguang ZhaoCancer Center, The First Hospital of Jilin University, Changchun, China.
Lei YangCancer Center, The First Hospital of Jilin University, Changchun, China.
Di WuCancer Center, The First Hospital of Jilin University, Changchun, China.
Hua HeCancer Center, The First Hospital of Jilin University, Changchun, China.
Mengmeng WangCancer Center, The First Hospital of Jilin University, Changchun, China.
Tingwen GeCancer Center, The First Hospital of Jilin University, Changchun, China.
Yudi LiuCancer Center, The First Hospital of Jilin University, Changchun, China.
Huimin TianCancer Center, The First Hospital of Jilin University, Changchun, China.
Jiuwei CuiCancer Center, The First Hospital of Jilin University, Changchun, China.
Lin JiaCancer Center, The First Hospital of Jilin University, Changchun, China.
Ziqiang WanCancer Center, The First Hospital of Jilin University, Changchun, China.
Fujun HanCancer Center, The First Hospital of Jilin University, Changchun, China.
First Hospital of Jilin University · CNJilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe conducted two meta-analyses of ATM genetic polymorphisms and cancer risk in individuals with or without radiation exposure to determine whether there was a joint effect between the ATM gene and radiation exposure in carcinogenesis.

resultsrs1801516, which was the only ATM polymorphism investigated by more than 3 studies of radiation exposure, was eligible for the present study. The meta-analysis of 23333 individuals without radiation exposure from 24 studies showed no association between the rs1801516 polymorphism and cancer risk, without heterogeneity across studies. The meta-analysis of 3787 individuals with radiation exposure from 6 studies showed a significant association between the rs1801516 polymorphism and a decreased cancer risk, with heterogeneity across studies. There was a borderline-significant difference between the ORs of the two meta-analyses (P = 0.066), and the difference was significant when only Caucasians were included (P = 0.011). MATERIALS AND

methodsPublications were identified by searching PubMed, EMBASE, Web of Science, and CNKI databases. Odds ratios (ORs) were calculated to estimate the association between ATM genetic polymorphisms and cancer risk. Tests of interaction were used to compare differences between the ORs of the two meta-analyses.

conclusionsOur meta-analyses confirmed the presence of a gene-environment interaction between the rs1801516 polymorphism and radiation exposure in carcinogenesis, whereas no association was found between the rs1801516 polymorphism and cancer risk for individuals without radiation exposure. The heterogeneity observed in the meta-analysis of individuals with radiation exposure might be due to gene-ethnicity or gene-gene interactions. Further studies are needed to elucidate sources of the heterogeneity.

Indexed as

Polymorphism, Single NucleotideRadiation ExposureAtaxia Telangiectasia Mutated ProteinsCarcinogenesisFemaleGene-Environment InteractionGenetic Association StudiesGenetic Predisposition to DiseaseHumansMaleOdds RatioRisk FactorsAtaxia Telangiectasia Mutated ProteinsATM protein, humanataxia telangiectasia-mutatedcarcinogenesisgene-environment interactionpolymorphismradiation

Identifiers

PMID27764772
PMCPMC5363555
OpenAlexW2537580030

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.