Evidence map›Paper›PMID 27764764›Full record

ArticlePhysiological genomics2016

Transcriptomic differences in intra-abdominal adipose tissue in extremely obese adolescents with different stages of NAFLD.

Ryan D Sheldon, Kayla M Kanosky, Kevin D Wells, Lili Miles, James W Perfield, Stavra Xanthakos, Thomas H Inge, R Scott Rector

Open access · bronzeAbstract read
In one paragraph

Article in Physiological genomics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ryan D SheldonResearch Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri.
Kayla M KanoskyResearch Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri.
Kevin D WellsDepartment of Animal Sciences, University of Missouri, Columbia, Missouri.
Lili MilesCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
James W PerfieldDepartment of Nutrition and Exercise Physiology, University of Missouri, Columbia, Missouri.
Stavra XanthakosCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
Thomas H IngeCincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
R Scott RectorResearch Service, Harry S. Truman Memorial Veterans Medical Center, Columbia, Missouri; rectors@health.missouri.edu.
Cincinnati Children's Hospital Medical Center · USUniversity of Missouri · USHarry S. Truman Memorial Veterans' Hospital · US

Funding

LCenter for Clinical and Translational Science and TrainingUL1TR001425 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., KISSELA, BRETT M · 2015 to 2024
$37.5M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI JANINE A HIGGINS · 1995 to 2026
$32.6M
Stem Cell/Organoid and Genome Editing CoreP30DK078392 · NIDDK · CINCINNATI CHILDRENS HOSP MED CTR · PI LEE ARMISTEAD DENSON · 2007 to 2026
$24.4M
Cincinnati Center for Clinical and Translational Sciences and TrainingUL1TR000077 · NCATS · UNIVERSITY OF CINCINNATI · PI HEUBI, JAMES E., TSEVAT, JOEL · 2012 to 2014
$9.9M
NCATS NIH HHS UL1 TR000077NCATS NIH HHS UL1 TR001425NIDDK NIH HHS P30 DK078392
6 · The paper itself

Abstract

Mechanisms responsible for progression of nonalcoholic fatty liver disease (NAFLD) to steatohepatitis (NASH) remain poorly defined. To examine the potential contribution of adipose tissue to NAFLD progression, we performed a complete transcriptomic analysis using RNA sequencing (RNA-Seq) on intra-abdominal adipose tissue (IAT) from severely obese adolescents [M

Indexed as

Adipose TissueAdolescentBariatric SurgeryBiopsyBody Mass IndexDown-RegulationFatty LiverFemaleGene Expression ProfilingHumansInsulin ResistanceIntra-Abdominal FatLiverMaleNon-alcoholic Fatty Liver DiseaseObesityRNA, Messengerchildhood obesitygene expressioninflammationRNA-Seqtranscriptomevisceral adipose tissue

Identifiers

PMID27764764
PMCPMC5206389
OpenAlexW2529774480

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.