Evidence map›Paper›PMID 27764699›Full record

ArticleNeoplasia (New York, N.Y.)2016

Fbxw7 Deletion Accelerates Kras

Qiang Zhang, Yaqing Zhang, Joshua D Parsels, Ines Lohse, Theodore S Lawrence, Marina Pasca di Magliano, Yi Sun, Meredith A Morgan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neoplasia (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 48 citations in OpenAlex.

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  12. Targeting the Hippo pathway in heart repair.Cardiovascular research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Qiang ZhangDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yaqing ZhangDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Joshua D ParselsDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ines LohseDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Theodore S LawrenceDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Marina Pasca di MaglianoDepartment of Surgery, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Yi SunDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA; Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou, China.
Meredith A MorganDepartment of Radiation Oncology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: mmccrack@med.umich.edu.
University of Michigan–Ann Arbor · USZhejiang University · CN

Funding

Translational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8M
Mechanisms of Pancreatic Inflammation, Tissue Repair and CarcinogenesisR01CA151588 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PASCA DI MAGLIANO, MARINA · 2010 to 2020
$3.3M
SAG E3 ubiquitin ligase in regulation of transformation and carcinogenesisR01CA118762 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUN, YI · 2006 to 2015
$2.6M
Dosage-Dependent Hedgehog Signaling in Pancreatic CancerR01CA198074 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALLEN, BENJAMIN, PASCA DI MAGLIANO, MARINA · 2015 to 2019
$1.9M
Selective Sensitization of Pancreatic Cancer to Therapy by Chk1 and PARP1 InhibitR01CA163895 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MORGAN, MEREDITH A · 2012 to 2016
$1.6M
Role of SAG/RBX2 E3 Ubiquitin Ligase in Skin CarcinogenesisR01CA171277 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SUN, YI · 2013 to 2017
$1.6M
NCI NIH HHS P50 CA130810NCI NIH HHS R01 CA118762NCI NIH HHS R01 CA151588NCI NIH HHS R01 CA163895NCI NIH HHS R01 CA171277NCI NIH HHS R01 CA198074
6 · The paper itself

Abstract

Pancreatic cancers driven by KRAS mutations require additional mutations for tumor progression. The tumor suppressor FBXW7 is altered in pancreatic cancers, but its contribution to pancreatic tumorigenesis is unknown. To determine potential cooperation between Kras mutation and Fbxw7 inactivation in pancreatic tumorigenesis, we generated P48-Cre;LSL-Kras

Indexed as

Gene DeletionGenes, rasAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell Line, TumorCell Transformation, NeoplasticChromosomal InstabilityF-Box ProteinsF-Box-WD Repeat-Containing Protein 7HumansMiceMice, KnockoutPancreatic NeoplasmsPhosphoproteinsTranscription FactorsAdaptor Proteins, Signal TransducingCell Cycle ProteinsF-Box ProteinsF-Box-WD Repeat-Containing Protein 7FBXW7 protein, humanPhosphoproteinsTranscription FactorsUbiquitin-Protein LigasesYAP1 protein, humanYAP-Signaling Proteins

Identifiers

PMID27764699
PMCPMC5071541
OpenAlexW2535437812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.