Evidence map›Paper›PMID 27764664›Full record

ReviewNeuron2016

Rapid Sensory Adaptation Redux: A Circuit Perspective.

Clarissa J Whitmire, Garrett B Stanley

Open access · bronzeAbstract readReview
In one paragraph

Review in Neuron, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 156 citations in OpenAlex.

  1. Article
  2. Illusory cold desensitizes touch.bioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. The Somatosensory Mismatch Negativity.The European journal of neuroscience · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Multiple Distinct Timescales of Rapid Sensory Adaption in the Thalamocortical Circuit.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Clarissa J WhitmireWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA.
Garrett B StanleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. Electronic address: garrett.stanley@bme.gatech.edu.
Georgia Institute of Technology · USThe Wallace H. Coulter Department of Biomedical Engineering · US

Funding

Thalamic synchrony and the gating of information flow to cortexR01NS048285 · NINDS · HARVARD UNIVERSITY · PI STANLEY, GARRETT B. · 2004 to 2014
$2.3M
In-vivo control of information flow by artificial stimulation: ephys and behaviorR01NS085447 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI STANLEY, GARRETT B. · 2013 to 2016
$1.2M
From Cells to Systems and Applications: Computational Neuroscience Training at EmT90DA032466 · NIDA · EMORY UNIVERSITY · PI JAEGER, DIETER, STANLEY, GARRETT B. · 2011 to 2015
$817k
Controlling thalamic state for somatosensory information flow in thalamusF31NS089412 · NINDS · GEORGIA INSTITUTE OF TECHNOLOGY · PI WHITMIRE, CLARISSA J · 2014 to 2016
$129k
NIDA NIH HHS T90 DA032466NINDS NIH HHS F31 NS089412NINDS NIH HHS R01 NS048285NINDS NIH HHS R01 NS085447
6 · The paper itself

Abstract

Adaptation is fundamental to life. All organisms adapt over timescales that span from evolution to generations and lifetimes to moment-by-moment interactions. The nervous system is particularly adept at rapidly adapting to change, and this in fact may be one of its fundamental principles of organization and function. Rapid forms of sensory adaptation have been well documented across all sensory modalities in a wide range of organisms, yet we do not have a comprehensive understanding of the adaptive cellular mechanisms that ultimately give rise to the corresponding percepts, due in part to the complexity of the circuitry. In this Perspective, we aim to build links between adaptation at multiple scales of neural circuitry by investigating the differential adaptation across brain regions and sub-regions and across specific cell types, for which the explosion of modern tools has just begun to enable. This investigation points to a set of challenges for the field to link functional observations to adaptive properties of the neural circuit that ultimately underlie percepts.

Indexed as

Adaptation, PhysiologicalBrainHumansNeural PathwaysNeuronal PlasticityNeuronsPerceptionSensationVision, OcularVisual PathwaysVisual Perception

Identifiers

PMID27764664
PMCPMC5076890
OpenAlexW2537800829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.