ArticlePLoS pathogens2016
Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals.
Article in PLoS pathogens, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01911065 (T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape), which is not on this map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
T Cell Responses to Varicella Zoster Virus After Vaccination and Viral Escape
Who cites it
46 citing papers in PubMed, 61 citations in OpenAlex.
- Early Pro-Inflammatory Signal and T-Cell Activation Associate With Vaccine-Induced Anti-Vaccinia Protective Neutralizing Antibodies.Frontiers in immunology · 2021Trial
- Th1 memory differentiates recombinant from live herpes zoster vaccines.The Journal of clinical investigation · 2018Trial
- Immune Responses to a Recombinant Glycoprotein E Herpes Zoster Vaccine in Adults Aged 50 Years or Older.The Journal of infectious diseases · 2018Trial
- Antigen-specific TScience advances · 2026Article
- Sustained mTORC1 activation in activated T cells impairs vaccine responses in older individuals.Science advances · 2025Article
- Peste des petits ruminants virus virulence is associated with an early inflammatory profile in the tonsils and cell cycle arrest in lymphoid tissue.Microbiology spectrum · 2025Article
- Metabolic Signaling as a Driver of T Cell Aging.Immune network · 2025Review
- Immune Response to an Adjuvanted Recombinant Zoster Vaccine in Japanese Patients with Rheumatoid Arthritis Receiving Upadacitinib (End Zoster-J Study): Study Protocol for an Exploratory Parallel Triple-Arm Prospective Trial.Journal of clinical medicine · 2024Article
- Immunogenicity of Recombinant Zoster Vaccine: A Systematic Review, Meta-Analysis, and Meta-Regression.Vaccines · 2024Review
- Review
- Immunogenicity in Mice Immunized with Recombinant Adenoviruses Expressing Varicella-Zoster Virus Envelope Glycoprotein E.Viruses · 2023Article
- T cell fate decisions during memory cell generation with aging.Seminars in immunology · 2023Review
- Memory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children.NPJ vaccines · 2023Article
- CISH impairs lysosomal function in activated T cells resulting in mitochondrial DNA release and inflammaging.Nature aging · 2023Article
- Heterogeneity of memory T cells in aging.Frontiers in immunology · 2023Review
- Hallmarks of the aging T-cell system.The FEBS journal · 2021Review
- The frequency of interleukin-1β-producing monocytes is significantly associated with varicella-zoster responses of nursing home residents.Clinical and experimental immunology · 2021Article
- Agricultural Pesticides and Shingles Risk in a Prospective Cohort of Licensed Pesticide Applicators.Environmental health perspectives · 2021Article
- miR-181a-regulated pathways in T-cell differentiation and aging.Immunity & ageing : I & A · 2021Review
- Systems Biological Analysis of Immune Response to Influenza Vaccination.Cold Spring Harbor perspectives in medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
Abstract
Vaccination with attenuated live varicella zoster virus (VZV) can prevent zoster reactivation, but protection is incomplete especially in an older population. To decipher the molecular mechanisms underlying variable vaccine responses, T- and B-cell responses to VZV vaccination were examined in individuals of different ages including identical twin pairs. Contrary to the induction of VZV-specific antibodies, antigen-specific T cell responses were significantly influenced by inherited factors. Diminished generation of long-lived memory T cells in older individuals was mainly caused by increased T cell loss after the peak response while the expansion of antigen-specific T cells was not affected by age. Gene expression in activated CD4 T cells at the time of the peak response identified gene modules related to cell cycle regulation and DNA repair that correlated with the contraction phase of the T cell response and consequently the generation of long-lived memory cells. These data identify cell cycle regulatory mechanisms as targets to reduce T cell attrition in a vaccine response and to improve the generation of antigen-specific T cell memory, in particular in an older population.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.